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Comparative Efficacy of Intravenous With Intra-articular Versus Intravenous Only Administration of Tranexamic Acid to Reduce Blood Loss in Knee Arthroplasty

Title
Comparative Efficacy of Intravenous With Intra-articular Versus Intravenous Only Administration of Tranexamic Acid to Reduce Blood Loss in Knee Arthroplasty
Authors
Kim, Young-HooPandey, KetanPark, Jang-WonKim, Jun-Shik
Ewha Authors
김영후김준식박장원
SCOPUS Author ID
김영후scopus; 김준식scopus; 박장원scopus
Issue Date
2018
Journal Title
ORTHOPEDICS
ISSN
0147-7447JCR Link

1938-2367JCR Link
Citation
ORTHOPEDICS vol. 41, no. 6, pp. E827 - E830
Publisher
SLACK INC
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
The objective of this study was to ascertain whether combined intravenous (IV) and intra-articular (IA) administration of tranexamic acid (TXA) is beneficial for reducing blood loss and the prevalence of deep venous thrombosis (DVT) in primary simultaneous bilateral total knee arthroplasty compared with IV only administration of TXA. One hundred fifty-four patients received a combined IV and IA injection of TXA in 1 knee and an IV only injection of TXA in the other. Transfusion rates and volumes and the amount of blood loss were recorded at 8 hours, 24 hours, and 48 hours. In addition, the authors ascertained whether the prevalence of DVT was higher in the patients with combined IV and IA administration of TXA than in the patients with IV only administration of TXA. Overall total blood loss was not significantly different (299.6 mL vs 280.1 mL, P = .22) between the 2 groups. The prevalence of DVT was 11% (17 knees) in the combined IV and IA group and 14% (22 knees) in the IV only group. This difference was not significant (P = .25). Combined IV and IA administration of TXA in bilateral total knee arthroplasty has no additional benefit in reducing total blood loss when compared with IV only administration. The prevalence of DVT was low and not significantly different between the 2 groups. Furthermore, no pulmonary embolism was found in either group.
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DOI
10.3928/01477447-20180912-09
Appears in Collections:
의과대학 > 의학과 > Journal papers
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