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DNA-Grafted Poly(acrylic acid) for One-Step DNA Functionalization of Iron Oxide Nanoparticles

Title
DNA-Grafted Poly(acrylic acid) for One-Step DNA Functionalization of Iron Oxide Nanoparticles
Authors
Hu, XiaoleKim, Chan-JinAlbert, Shine K.Park, So-Jung
Ewha Authors
박소정김찬진
SCOPUS Author ID
박소정scopus; 김찬진scopus
Issue Date
2018
Journal Title
LANGMUIR
ISSN
0743-7463JCR Link
Citation
LANGMUIR vol. 34, no. 47, pp. 14342 - 14346
Publisher
AMER CHEMICAL SOC
Indexed
SCI; SCIE; SCOPUS WOS
Document Type
Article
Abstract
Here, we report one-step DNA functionalization of hydrophobic iron oxide nanoparticles (IONPs) using DNA-grafted poly(acrylic acid) (PAA-g-DNA). PAA-g-DNA was synthesized by coupling PAA to amine-modified oligonucleotides via solid-phase amide chemistry, which yielded PAA grafted with multiple DNA strands with high graft efficiencies. Synthesized PAA-g-DNA was utilized as a phase-transfer and DNA functionalization agent for hydrophobic IONPs, taking advantage of unreacted carboxylic acid groups. The resulting DNA-modified IONPs were well dispersed in aqueous solutions and possessed DNA binding properties characteristic of polyvalent DNA nanostructures, showing that this approach provides a simple one-step method for DNA functionalization of hydrophobic IONPs.
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DOI
10.1021/acs.langmuir.8b03119
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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