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Seongsanamides A-D: Antiallergic Bicyclic Peptides from Bacillus safensis KCTC 12796BP

Title
Seongsanamides A-D: Antiallergic Bicyclic Peptides from Bacillus safensis KCTC 12796BP
Authors
Kim G.J.Li X.Kim S.-H.Yang I.Hahn D.Chin J.Nam S.-J.Nam J.-W.Nam D.H.Oh D.-C.Chang H.W.Choi H.
Ewha Authors
남상집
SCOPUS Author ID
남상집scopusscopus
Issue Date
2018
Journal Title
Organic Letters
ISSN
1523-7060JCR Link
Citation
Organic Letters vol. 20, no. 23, pp. 7539 - 7543
Publisher
American Chemical Society
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Six seongsanamides were isolated from the culture broth of Bacillus safensis KCTC 12796BP, and their structures were elucidated by spectroscopic data analysis combined with Marfey's method, electronic circular dichroism calculations, and biosynthetic gene cluster analysis. Compounds 1-4 were bicyclic peptides with isodityrosine residues; 5 and 6 were monocyclic peptides. Only the bicyclic seongsanamides inhibited degranulation and LTC4/PGD2 generation in IgE/Ag-stimulated bone marrow-derived mast cells. Oral administration of 1 suppressed mast cell-dependent passive cutaneous anaphylaxis reaction. © 2018 American Chemical Society.
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DOI
10.1021/acs.orglett.8b03293
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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