Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이경림 | * |
dc.contributor.author | 서은경 | * |
dc.date.accessioned | 2018-12-14T16:31:20Z | - |
dc.date.available | 2018-12-14T16:31:20Z | - |
dc.date.issued | 2018 | * |
dc.identifier.issn | 0944-7113 | * |
dc.identifier.other | OAK-22374 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/247895 | - |
dc.description.abstract | Background: We previously reported that the biologically active form of histamine releasing factor (HRF) is dimerized translationally controlled tumor protein (dTCTP) which is involved in a number of allergic diseases. Hypothesis/purpose: Hoping that agents that modulate dTCTP may provide new therapeutic targets to allergic inflammatory diseases, we screened a library of natural products for substances that inhibit dTCTP. One such inhibitor we found was dehydrocostus lactone (DCL), a natural sesquiterpene present in rhizome of Saussurea lappa Clarke, the subject of this study. Methods: We evaluated the therapeutic efficacy of DCL in a mouse model of ovalbumin (OVA)-induced allergic airway inflammation, employing the ELISA system using BEAS-2B cells and splenocytes, and confirmed that DCL interacts with dTCTP using SPR assay. Results: DCL inhibited dTCTP-induced secretion of IL-8 in BEAS-2B cells. From kinetic analysis of dTCTP and DCL, we found that KD value was 5.33 ± 0.03 μM between dTCTP and DCL. DCL also significantly reduced inflammatory lung eosinophilia, type 2 cytokines in BALF, as well as OVA specific IgE and mucus production in a mouse model of ovalbumin induced allergy. Moreover, DCL suppressed NF-κB activation. Conclusion: DCL's therapeutic potential in allergic airway inflammation is based on its anti-inflammatory activity of suppressing the function of dTCTP. © 2018 Elsevier GmbH | * |
dc.description.sponsorship | Ministry of Science, ICT and Future Planning | * |
dc.language | English | * |
dc.publisher | Elsevier GmbH | * |
dc.subject | Allergic diseases | * |
dc.subject | Dehydrocostus lactone | * |
dc.subject | Dimerized TCTP | * |
dc.subject | Histamine releasing factor | * |
dc.subject | Saussurea lappa Clarke | * |
dc.title | Dehydrocostus lactone, a sesquiterpene from Saussurea lappa Clarke, suppresses allergic airway inflammation by binding to dimerized translationally controlled tumor protein | * |
dc.type | Article | * |
dc.relation.volume | 43 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 46 | * |
dc.relation.lastpage | 54 | * |
dc.relation.journaltitle | Phytomedicine | * |
dc.identifier.doi | 10.1016/j.phymed.2018.03.045 | * |
dc.identifier.wosid | WOS:000432722700006 | * |
dc.identifier.scopusid | 2-s2.0-85045068838 | * |
dc.author.google | Pyun H. | * |
dc.author.google | Kang U. | * |
dc.author.google | Seo E.K. | * |
dc.author.google | Lee K. | * |
dc.contributor.scopusid | 이경림(7501517435) | * |
dc.contributor.scopusid | 서은경(7005953758) | * |
dc.date.modifydate | 20240501081003 | * |