DSpace at EWHA: Antartin, a cytotoxic zizaane-type Sesquiterpenoid from a Streptomyces sp. Isolated from an antarctic marine sediment

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Antartin, a cytotoxic zizaane-type Sesquiterpenoid from a Streptomyces sp. Isolated from an antarctic marine sediment

Title: Antartin, a cytotoxic zizaane-type Sesquiterpenoid from a Streptomyces sp. Isolated from an antarctic marine sediment

Authors: Kim D.; Lee E.J.; Lee J.; Leutou A.S.; Shin Y.-H.; Choi B.; Hwang J.S.; Hahn D.; Choi H.; Chin J.; Cho S.J.; Hong Y.D.; Ko J.; Seong C.N.; Maloney K.N.; Oh D.-C.; Yang I.; Hwang H.; Nam S.-J.

Keywords: Cold water natural product; Marine natural product; Streptomyces sp.; Zizaane-type sesquiterpenoid

Abstract: Antartin (1), a new zizaane-type sesquiterpene, was isolated from Streptomyces sp. SCO736. The chemical structure of 1 was assigned from the interpretation of 1D and 2D NMR in addition to mass spectrometric data. The relative stereochemistry of 1 was determined by analysis of NOE data, while the absolute stereochemistry was decided based on a comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Antartin (1) showed cytotoxicity against A549, H1299, and U87 cancer cell lines by causing cell cycle arrest at the G1 phase. © 2018 by the authors.