Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤주영 | * |
dc.date.accessioned | 2018-12-14T16:31:04Z | - |
dc.date.available | 2018-12-14T16:31:04Z | - |
dc.date.issued | 2018 | * |
dc.identifier.issn | 1359-7345 | * |
dc.identifier.other | OAK-22512 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/247798 | - |
dc.description.abstract | Two 'turn on' TCF-based fluorescence probes were developed for the detection of biological thiols (TCF-GSH and TCFCl-GSH). TCF-GSH was shown to have a high sensitivity towards glutathione (GSH) with a 0.28 μM limit of detection. Unfortunately, at higher GSH concentrations the fluorescence intensity of TCF-GSH decreased and toxicity was observed for TCF-GSH in live cells. However, TCFCl-GSH was shown to be able to detect GSH at biologically relevant concentrations with a 0.45 μM limit of detection. No toxicity was found for TCFCl-GSH and a clear 'turn on' with good photostability was observed for the exogenous addition of GSH, Cys and HCys. Furthermore, TCFCl-GSH was used to evaluate the effects of drug treatment on the levels of GSH in live cells. © The Royal Society of Chemistry 2018. | * |
dc.description.sponsorship | National Research Foundation of Korea | * |
dc.language | English | * |
dc.publisher | Royal Society of Chemistry | * |
dc.title | Long-wavelength TCF-based fluorescence probes for the detection and intracellular imaging of biological thiols | * |
dc.type | Article | * |
dc.relation.issue | 38 | * |
dc.relation.volume | 54 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 4786 | * |
dc.relation.lastpage | 4789 | * |
dc.relation.journaltitle | Chemical Communications | * |
dc.identifier.doi | 10.1039/c8cc01661e | * |
dc.identifier.wosid | WOS:000431740500007 | * |
dc.identifier.scopusid | 2-s2.0-85046835902 | * |
dc.author.google | Sedgwick A.C. | * |
dc.author.google | Gardiner J.E. | * |
dc.author.google | Kim G. | * |
dc.author.google | Yevglevskis M. | * |
dc.author.google | Lloyd M.D. | * |
dc.author.google | Jenkins A.T.A. | * |
dc.author.google | Bull S.D. | * |
dc.author.google | Yoon J. | * |
dc.author.google | James T.D. | * |
dc.contributor.scopusid | 윤주영(7403587371) | * |
dc.date.modifydate | 20240118162450 | * |