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Xylobiose prevents high-fat diet induced mice obesity by suppressing mesenteric fat deposition and metabolic dysregulation

Title
Xylobiose prevents high-fat diet induced mice obesity by suppressing mesenteric fat deposition and metabolic dysregulation
Authors
Lim S.-M.Kim E.Shin J.-H.Seok P.R.Jung S.Yoo S.-H.Kim Y.
Ewha Authors
김유리
SCOPUS Author ID
김유리scopus
Issue Date
2018
Journal Title
Molecules
ISSN
1420-3049JCR Link
Citation
Molecules vol. 23, no. 3
Keywords
AdipogenesisInflammationLipogenesisMesenteric adipose tissueObesityXylobiose
Publisher
MDPI AG
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Obesity is a public concern and is responsible for various metabolic diseases. Xylobiose (XB), an alternative sweetener, is a major component of xylo-oligosaccharide. The purpose of this study was to investigate the effects of XB on obesity and its associated metabolic changes in related organs. For these studies, mice received a 60% high-fat diet supplemented with 15% D-xylose, 10% XB, or 15% XB as part of the total sucrose content of the diet for ten weeks. Body weight, fat and liver weights, fasting blood glucose, and blood lipids levels were significantly reduced with XB supplementation. Levels of leptin and adipokine were also improved and lipogenic and adipogenic genes in mesenteric fat and liver were down-regulated with XB supplementation. Furthermore, pro-inflammatory cytokines, fatty acid uptake, lipolysis, and β-oxidation-related gene expression levels in mesenteric fat were down-regulated with XB supplementation. Thus, XB exhibited therapeutic potential for treating obesity which involved suppression of fat deposition and obesity-related metabolic disorders. © 2018 by the authors.
DOI
10.3390/molecules23030705
Appears in Collections:
신산업융합대학 > 식품영양학과 > Journal papers
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