View : 282 Download: 69
Some biological consequences of the inhibition of Na,K-ATPase by translationally controlled tumor protein (TCTP)
- Some biological consequences of the inhibition of Na,K-ATPase by translationally controlled tumor protein (TCTP)
- Jung J.; Ryu S.; Ki I.A.; Woo H.A.; Lee K.
- Ewha Authors
- 이경림; 우현애
- SCOPUS Author ID
- 이경림; 우현애
- Issue Date
- Journal Title
- International Journal of Molecular Sciences
- International Journal of Molecular Sciences vol. 19, no. 6
- Autophagy; Hypertension; K-ATPase; Na; Translationally controlled tumor protein; Tumorigenesis
- MDPI AG
- Document Type
Show the fulltext
- Na,K-ATPase is an ionic pump that regulates the osmotic equilibrium and membrane potential of cells and also functions as a signal transducer. The interaction of Na,K-ATPase with translationally controlled tumor protein (TCTP) results, among others, in the inhibition of the former’s pump activity and in the initiation of manifold biological and pathological phenomena. These phenomena include hypertension and cataract development in TCTP-overexpressing transgenic mice, as well as the induction of tumorigenesis signaling pathways and the activation of Src that ultimately leads to cell proliferation and migration. This review attempts to collate the biological effects of Na,K-ATPase and TCTP interaction and suggests that this interaction has the potential to serve as a possible therapeutic target for selected diseases. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
- Files in This Item:
Some biological consequences.pdf(2.48 MB)
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.