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Some biological consequences of the inhibition of Na,K-ATPase by translationally controlled tumor protein (TCTP)

Title
Some biological consequences of the inhibition of Na,K-ATPase by translationally controlled tumor protein (TCTP)
Authors
Jung J.Ryu S.Ki I.A.Woo H.A.Lee K.
Ewha Authors
이경림우현애
SCOPUS Author ID
이경림scopus; 우현애scopus
Issue Date
2018
Journal Title
International Journal of Molecular Sciences
ISSN
1661-6596JCR Link
Citation
International Journal of Molecular Sciences vol. 19, no. 6
Keywords
AutophagyHypertensionK-ATPaseNaTranslationally controlled tumor proteinTumorigenesis
Publisher
MDPI AG
Indexed
SCOPUS WOS scopus
Document Type
Review
Abstract
Na,K-ATPase is an ionic pump that regulates the osmotic equilibrium and membrane potential of cells and also functions as a signal transducer. The interaction of Na,K-ATPase with translationally controlled tumor protein (TCTP) results, among others, in the inhibition of the former’s pump activity and in the initiation of manifold biological and pathological phenomena. These phenomena include hypertension and cataract development in TCTP-overexpressing transgenic mice, as well as the induction of tumorigenesis signaling pathways and the activation of Src that ultimately leads to cell proliferation and migration. This review attempts to collate the biological effects of Na,K-ATPase and TCTP interaction and suggests that this interaction has the potential to serve as a possible therapeutic target for selected diseases. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.
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DOI
10.3390/ijms19061657
Appears in Collections:
약학대학 > 약학과 > Journal papers
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