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Facile direct synthesis of unsymmetrical ureas from N-Alloc-, N-Cbz-, and N-Boc-protected amines using DABAL-Me3
- Title
- Facile direct synthesis of unsymmetrical ureas from N-Alloc-, N-Cbz-, and N-Boc-protected amines using DABAL-Me3
- Authors
- Kang S.; Kim H.-K.
- Ewha Authors
- 강수성
- SCOPUS Author ID
- 강수성
- Issue Date
- 2018
- Journal Title
- Tetrahedron
- ISSN
- 0040-4020
- Citation
- Tetrahedron vol. 74, no. 30, pp. 4036 - 4046
- Keywords
- DABAL-Me3; Protected carbamates; Unsymmetrical ureas; Urea synthesis
- Publisher
- Elsevier Ltd
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- A practical synthetic method for the direct synthesis of unsymmetrically substituted ureas from N-Alloc-, N-Cbz-, and N-Boc-protected amines is described. In this study, efficient direct conversion of the Alloc-, Cbz-, and Boc-carbamate compounds to ureas was achieved in the presence of DABAL-Me3, an air stable and easily handled reagent. Using this reaction method, both protected aromatic and aliphatic amines were successfully transformed into various trisubstituted and tetrasubstituted ureas with high yields without side product. Our findings offer promising guidelines for direct preparation of useful ureas from N-Alloc-, N-Cbz-, and N-Boc-carbamates. © 2018 Elsevier Ltd
- DOI
- 10.1016/j.tet.2018.06.011
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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