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Design and applications of fluorescent detectors for peroxynitrite
- Title
- Design and applications of fluorescent detectors for peroxynitrite
- Authors
- Wang, Shan; Chen, Liyan; Jangili, Paramesh; Sharma, Amit; Li, Wei; Hou, Ji-Ting; Qin, Caiqin; Yoon, Juyoung; Kim, Jong Seung
- Ewha Authors
- 윤주영
- SCOPUS Author ID
- 윤주영
- Issue Date
- 2018
- Journal Title
- COORDINATION CHEMISTRY REVIEWS
- ISSN
- 0010-8545
1873-3840
- Citation
- COORDINATION CHEMISTRY REVIEWS vol. 374, pp. 36 - 54
- Keywords
- Fluorescence probes; Peroxynitrite; Boronic acids or boronates; N-dearylation; Intracellular imaging; In vivo imaging; Reactive oxygen species (ROS)
- Publisher
- ELSEVIER SCIENCE SA
- Indexed
- SCIE; SCOPUS
- Document Type
- Review
- Abstract
- Peroxynitrite (ONOO-) is one of the endogenous reactive oxygen species (ROS), which causes damage to a wide array of molecular components in the cells, including DNA and proteins, owing to its high oxidizing as well as nitrating properties. However, the precise pathogenic roles played by this substance in biological systems have not yet been elucidated completely owing to its short lifetime, high reactivity, low concentration and elusive nature in the in vivo applications. Thus, the development of more sensitive and selective techniques for detecting ONOO-, with high biocompatibilities, sensitivities, and site specificities, is a significant goal. This review summarizes the recent advances that have been made in developing fluorescent sensors for ONOO- and their biological applications in diverse living systems. (C) 2018 Elsevier B.V. All rights reserved
- DOI
- 10.1016/j.ccr.2018.06.013
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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