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Neuromyopathy caused by long term colchicine therapy
- Title
- Neuromyopathy caused by long term colchicine therapy
- Authors
- Park, Hyung Jun; Lee, Hyung-Soo; Koo, Heasoo; Han, Soo Jeong; Choi, Euno; Lee, Chan Young; Lee, Seung Ah; Choi, Young-Chul; Park, Kee Duk
- Ewha Authors
- 박기덕; 한수정
- SCOPUS Author ID
- 박기덕; 한수정
- Issue Date
- 2018
- Journal Title
- NEUROLOGY ASIA
- ISSN
- 1823-6138
- Citation
- NEUROLOGY ASIA vol. 23, no. 2, pp. 185 - 188
- Keywords
- colchicine; toxicity; muscular disease; polyneuropathies
- Publisher
- ASEAN NEUROLOGICAL ASSOC
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Colchicine-induced neuromyopathy is an extremely rare complication, and can develop in the setting of acute overdose or chronic administration in therapeutic doses. A 72-year-old man presented with proximal muscle weakness and myalgia. He had angina pectoris and Behcet's disease, leading to the treatment of colchicine (1.2 mg daily for about 6 years), cyclosporine, methylprednisolone, simvastatin, and aspirin. A biceps brachii muscle biopsy was performed and electron microscopic examination revealed scattered autophagic vacuoles. He was initially treated with steroid pulse therapy. However, muscle weakness did not improve. After the discontinuation of colchicine, muscle power and myalgia improved steadily. There should be heightened awareness of colchicine-induced neuromyopathy because that clinical suspicion is the most important diagnostic clue, and termination of colchicine is the only treatment.
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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