Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이윤실 | * |
dc.date.accessioned | 2018-12-14T16:30:31Z | - |
dc.date.available | 2018-12-14T16:30:31Z | - |
dc.date.issued | 2018 | * |
dc.identifier.issn | 1422-0067 | * |
dc.identifier.other | OAK-22827 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/247607 | - |
dc.description.abstract | The expansion of mobile phone use has raised questions regarding the possible biological effects of radiofrequency electromagnetic field (RF-EMF) exposure on oxidative stress and brain inflammation. Despite accumulative exposure of humans to radiofrequency electromagnetic fields (RF-EMFs) from mobile phones, their long-term effects on oxidative stress and neuroinflammation in the aging brain have not been studied. In the present study, middle-aged C57BL/6 mice (aged 14 months) were exposed to 1950 MHz electromagnetic fields for 8 months (specific absorption rate (SAR) 5 W/kg, 2 h/day, 5 d/week). Compared with those in the young group, levels of protein (3-nitro-tyrosine) and lipid (4-hydroxy-2-nonenal) oxidative damage markers were significantly increased in the brains of aged mice. In addition, levels of markers for DNA damage (8-hydroxy-2'-deoxyguanosine, p53, p21, gamma H2AX, and Bax), apoptosis (cleaved caspase-3 and cleaved poly(ADP-ribose) polymerase 1 (PARP-1)), astrocyte (GFAP), and microglia (Iba-1) were significantly elevated in the brains of aged mice. However, long-term RF-EMF exposure did not change the levels of oxidative stress, DNA damage, apoptosis, astrocyte, or microglia markers in the aged mouse brains. Moreover, long-term RF-EMF exposure did not alter locomotor activity in aged mice. Therefore, these findings indicate that long-term exposure to RF-EMF did not influence age-induced oxidative stress or neuroinflammation in C57BL/6 mice. | * |
dc.language | English | * |
dc.publisher | MDPI | * |
dc.subject | RF-EMF | * |
dc.subject | oxidative stress | * |
dc.subject | DNA damage | * |
dc.subject | neuroinflammation | * |
dc.subject | aged brain | * |
dc.title | Impact of Long-Term RF-EMF on Oxidative Stress and Neuroinflammation in Aging Brains of C57BL/6 Mice | * |
dc.type | Article | * |
dc.relation.issue | 7 | * |
dc.relation.volume | 19 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | * |
dc.identifier.doi | 10.3390/ijms19072103 | * |
dc.identifier.wosid | WOS:000442807400282 | * |
dc.identifier.scopusid | 2-s2.0-85050581134 | * |
dc.author.google | Jeong, Ye Ji | * |
dc.author.google | Son, Yeonghoon | * |
dc.author.google | Han, Na-Kyung | * |
dc.author.google | Choi, Hyung-Do | * |
dc.author.google | Pack, Jeong-Ki | * |
dc.author.google | Kim, Nam | * |
dc.author.google | Lee, Yun-Sil | * |
dc.author.google | Lee, Hae-June | * |
dc.contributor.scopusid | 이윤실(17137192000) | * |
dc.date.modifydate | 20240130115944 | * |