View : 239 Download: 0

A Two-Photon Fluorescent Probe for Imaging Endogenous ONOO(- )near NMDA Receptors in Neuronal Cells and Hippocampal Tissues

Title
A Two-Photon Fluorescent Probe for Imaging Endogenous ONOO(- )near NMDA Receptors in Neuronal Cells and Hippocampal Tissues
Authors
Lee, DayoungLim, Chang SuKo, GyeongjuKim, DayoungCho, Myoung KiNam, Sang-JipKim, Hwan MyungYoon, Juyoung
Ewha Authors
윤주영남상집
SCOPUS Author ID
윤주영scopus; 남상집scopusscopus
Issue Date
2018
Journal Title
ANALYTICAL CHEMISTRY
ISSN
0003-2700JCR Link

1520-6882JCR Link
Citation
ANALYTICAL CHEMISTRY vol. 90, no. 15, pp. 9347 - 9352
Publisher
AMER CHEMICAL SOC
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
In this study, we developed a two-photon fluorescent probe for detection of peroxynitrite (ONOO-) near the N-methyl-D-aspartate (NMDA) receptor. This naphthalimide-based probe contains a boronic acid reactive group and an ifenprodil-like tail, which serves as an NMDA receptor targeting unit. The probe displays high sensitivity and selectivity, along with a fast response time in aqueous solution. More importantly, the probe can be employed along with two-photon fluorescence microscopy to detect endogenous ONOO- near NMDA receptors in neuronal cells as well as in hippocampal tissues. The results suggest that the probe has the potential of serving as a useful imaging tool for studying ONOO- related diseases in the nervous system.
Show the fulltext
DOI
10.1021/acs.analchem.8b01960
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE