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Severe glyphosate-surfactant intoxication: Successful treatment with continuous renal replacement therapy
- Title
- Severe glyphosate-surfactant intoxication: Successful treatment with continuous renal replacement therapy
- Authors
- Lee D.H.; Choi Y.H.
- Ewha Authors
- 최윤희
- SCOPUS Author ID
- 최윤희
- Issue Date
- 2017
- Journal Title
- Hong Kong Journal of Emergency Medicine
- ISSN
- 1024-9079
- Citation
- Hong Kong Journal of Emergency Medicine vol. 24, no. 1, pp. 40 - 44
- Keywords
- Glycine; Herbicide; Human; Multiple organ failure; Poisoning
- Publisher
- Medcom Limited
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Glyphosate-surfactant is one of the most commonly used herbicides in the world. Its key component, glyphosate, is a competitive inhibitor of the shikimate pathway, a metabolic pathway found only in plants. However, severe intoxication, including lethal cases by ingestion of, glyphosate-surfactant has been reported. We describe the full recovery of two patients from glyphosate-polyoxyethyleneamine surfactant intoxication and multi-organ system failure following continuous renal replacement therapy. Both patients developed persistent shock, acute kidney injury, lactic acidosis, hyperkalaemia and multi-organ failure despite of resuscitation. We believe that continuous renal replacement therapy should be initiated immediately for removal of glyphosate-polyoxyethyleneamine surfactant in patients with signs of cardiopulmonary compromise, lactic acidosis, and renal failure. We propose the addition of glyphosate-polyoxyethyleneamine surfactant to the list of toxins for which early haemodialysis should be indicated. © 2017, Medcom Limited. All rights reserved.
- DOI
- 10.1177/102490791702400107
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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