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Prognostic role of the MicroRNA-200 family in various carcinomas: A systematic review and meta-analysis
- Title
- Prognostic role of the MicroRNA-200 family in various carcinomas: A systematic review and meta-analysis
- Authors
- Lee J.S.; Ahn Y.-H.; Won H.S.; Sun D.S.; Kim Y.H.; Ko Y.H.
- Ewha Authors
- 안영호
- SCOPUS Author ID
- 안영호
- Issue Date
- 2017
- Journal Title
- BioMed Research International
- ISSN
- 2314-6133
- Citation
- BioMed Research International vol. 2017
- Publisher
- Hindawi Limited
- Indexed
- SCIE; SCOPUS
- Document Type
- Review
- Abstract
- Background/Aims. The miRNA-200 (miR-200) family may act as key inhibitors of epithelial-to-mesenchymal transition. However, the potential prognostic value of miR-200s in various human malignancies remains controversial. This meta-analysis analyzed the associations between miR-200 levels and survival outcomes in a variety of tumors. Methods. Eligible published studies were identified by searching theEmbase, PubMed, CINAHL, andGoogle scholar databases. Patient clinical data were pooled, and pooled hazard ratios (HRs) with 95% confidence intervals (95% CI) were used to calculate the strength of this association. Results. The pooled HRs suggested that high tissue expression of miR-200 family members was associated with better survival (overall survival [OS]: HR = 0.70, 95% CI 0.54-0.91; progression-free survival [PFS]: HR = 0.63, 95% CI 0.52-0.76) in thirty-four eligible articles. In contrast, higher expression of circulating miR-200 members was significantly associated with poor clinical outcome (OS, HR = 1.68, 95% CI 1.15-2.46; PFS, HR = 2.62, 95% CI 1.68-4.07). Conclusion. The results from this meta-analysis suggest that miR-200 family members are potential prognostic biomarkers in patients with various carcinomas. To apply these findings in the clinic, large prospective studies are needed to validate the prognostic values of miR-200s in individual cancer types. © Copyright 2017 Jung Soo Lee et al.
- DOI
- 10.1155/2017/1928021
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
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