Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 성순희 | * |
dc.contributor.author | 조민선 | * |
dc.contributor.author | 박상희 | * |
dc.date.accessioned | 2018-12-07T16:30:37Z | - |
dc.date.available | 2018-12-07T16:30:37Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 0003-9985 | * |
dc.identifier.other | OAK-20816 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/247374 | - |
dc.description.abstract | Context: Because of the limited number of available primary bladder paraganglioma (PBPG) cases, the rates of succinate dehydrogenase (SDH) mutations and the clini-copathologic characteristics of SDH-deficient tumors have not been fully studied. Objective: To define the clinicopathologic and molecular characteristics of PBPGs. Design: A total of 52 PBPGs were collected retrospectively. SDHA and SDHB immunohistochemical stains were performed. In cases of SDHB expression loss, mutation analyses of SDHB, SDHC, and SDHD were performed. Results: The clinicopathologic features were analyzed for 52 cases (M:F = 27:25), with a mean age of 56 years (range, 22-79 years). Tumor sizes were 0.5 to 8 cm (mean, 2.4 cm). Tumor necrosis was present in 5 of 52 cases (10%), involvement of muscularis propria in 41 (79%), and lymphovascular tumor invasion in 6 (12%). During a mean follow-up period of 41 months (range, 1-161 months), 3 of 52 patients (6%) developed metastases, but no one died from the disease. Immunohistochemistry for SDHA and SDHB showed that all cases were SDHA intact. Among them, 43 cases had intact SDHB, whereas 9 cases were SDHB deficient. Compared with the SDHB-intact cases, the SDHB-deficient cases were characterized by large tumor sizes (4.5 versus 1.9 cm; P <.001), a higher number of mitoses per 10 high-powered fields (2.6 versus 0.1; P =.002), and frequent lymphovascular tumor invasion (33% versus 7%; P =.02) and metastases (22% versus 2%; P =.02). Mutational analyses for SDHB, SDHC, and SDHD were performed in 9 SDHB-deficient cases. Among them, 6 cases were successfully sequenced and revealed SDHB mutations only. Conclusions: Large tumor size, a higher number of mitoses, and the presence of lymphovascular tumor invasion and SDHB mutations suggest malignant paraganglioma. | * |
dc.language | English | * |
dc.publisher | College of American Pathologists | * |
dc.title | Clinicopathologic characteristics and mutational status of succinate dehydrogenase genes in paraganglioma of the urinary bladder: A multi-institutional Korean study | * |
dc.type | Article | * |
dc.relation.issue | 5 | * |
dc.relation.volume | 141 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 671 | * |
dc.relation.lastpage | 677 | * |
dc.relation.journaltitle | Archives of Pathology and Laboratory Medicine | * |
dc.identifier.doi | 10.5858/arpa.2016-0403-OA | * |
dc.identifier.wosid | WOS:000402173100007 | * |
dc.identifier.scopusid | 2-s2.0-85018360022 | * |
dc.author.google | Park S. | * |
dc.author.google | Kang S.Y. | * |
dc.author.google | Kwon G.Y. | * |
dc.author.google | Kwon J.E. | * |
dc.author.google | Kim S.K. | * |
dc.author.google | Kim J.Y. | * |
dc.author.google | Kim C.H. | * |
dc.author.google | Kim H.-J. | * |
dc.author.google | Moon K.C. | * |
dc.author.google | Pyo J.Y. | * |
dc.author.google | Park W.Y. | * |
dc.author.google | Park E.S. | * |
dc.author.google | Sung J.-Y. | * |
dc.author.google | Sung S.H. | * |
dc.author.google | Oh Y.-H. | * |
dc.author.google | Lee S.E. | * |
dc.author.google | Lee W. | * |
dc.author.google | Lee J.I. | * |
dc.author.google | Cho N.H. | * |
dc.author.google | Jung S.J. | * |
dc.author.google | Cho M.-S. | * |
dc.author.google | Cho Y.M. | * |
dc.author.google | Cho H.Y. | * |
dc.author.google | Cha E.J. | * |
dc.author.google | Chae Y.-S. | * |
dc.author.google | Choe G. | * |
dc.author.google | Choi Y.J. | * |
dc.author.google | Huh J. | * |
dc.author.google | Ro J.Y. | * |
dc.contributor.scopusid | 성순희(7202731948;58455037400) | * |
dc.contributor.scopusid | 조민선(13205279200) | * |
dc.contributor.scopusid | 박상희(12041890800) | * |
dc.date.modifydate | 20240220112152 | * |