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Impact of radiation dose in postoperative radiotherapy after R1 resection for extrahepatic bile duct cancer: Long term results from a single institution
- Title
- Impact of radiation dose in postoperative radiotherapy after R1 resection for extrahepatic bile duct cancer: Long term results from a single institution
- Authors
- Kim B.H.; Chie E.K.; Kim K.; Jang J.-Y.; Kim S.W.; Oh D.-Y.; Bang Y.-J.; Ha S.W.
- Ewha Authors
- 김규보
- SCOPUS Author ID
- 김규보
- Issue Date
- 2017
- Journal Title
- Oncotarget
- ISSN
- 1949-2553
- Citation
- Oncotarget vol. 8, no. 44, pp. 78076 - 78085
- Keywords
- Extrahepatic bile duct cancer; Postoperative radiotherapy; R1 resection; Radiation dose
- Publisher
- Impact Journals LLC
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Purpose: This study was conducted to evaluate the impact of radiation dose after margin involved resection in patients with extrahepatic bile duct cancer. Methods: Among the 251 patients who underwent curative resection followed by adjuvant chemoradiotherapy, 86 patients had either invasive carcinoma (n = 63) or carcinoma in situ (n = 23) at the resected margin. Among them, 54 patients received conventional radiation dose (40-50.4 Gy) and 32 patients received escalated radiation dose (54-56 Gy). Results: Escalated radiation dose was associated with improved locoregional control (5yr rate, 73.8% vs. 47.1%, p = 0.069), but not disease-free survival (5yr rate, 43.4% vs. 32.6%, p = 0.490) and overall survival (5yr rate, 40.6% vs. 29.6%, p = 0.348). In multivariate analysis for locoregional control, invasive carcinoma at the margin (HR 2.957, p = 0.032) and escalated radiation dose (HR 0.394, p = 0.047) were independent prognostic factors. No additional gastrointestinal toxicity was observed in escalated dose group. Conclusions: Delivery of radiation dose ≥ 54 Gy was well tolerated and associated with improved locoregional control, but not with overall survival after margin involved resection. Further validation study is warranted. © Kim et al.
- DOI
- 10.18632/oncotarget.17368
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
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