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Factors affecting treatment outcome in patients with idiopathic nonspecific interstitial pneumonia: a nationwide cohort study
- Title
- Factors affecting treatment outcome in patients with idiopathic nonspecific interstitial pneumonia: a nationwide cohort study
- Authors
- Lee S.H.; Park M.S.; Kim S.Y.; Kim D.S.; Kim Y.W.; Chung M.P.; Uh S.T.; Park C.S.; Park S.W.; Jeong S.H.; Park Y.B.; Lee H.L.; Shin J.W.; Lee E.J.; Lee J.H.; Jegal Y.; Lee H.K.; Kim Y.H.; Song J.W.; Park J.S.
- Ewha Authors
- 이진화
- SCOPUS Author ID
- 이진화
- Issue Date
- 2017
- Journal Title
- Respiratory research
- ISSN
- 1465-993X
- Citation
- Respiratory research vol. 18, no. 1, pp. 204
- Keywords
- Non-specific interstitial pneumonia; Pulmonary lung function; Treatment
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- BACKGROUND: The effects of corticosteroid-based therapy in patients with idiopathic nonspecific interstitial pneumonia (iNSIP), and factors affecting treatment outcome, are not fully understood. We aimed to investigate the long-term treatment response and factors affecting the treatment outcome in iNSIP patients from a multi-center study in Korea.METHODS: The Korean interstitial lung disease (ILD) Study Group surveyed ILD patients from 2003 to 2007. Patients were divided into two groups to compare the treatment response: response group (forced vital capacity (FVC) improves ≥10% after 1 year) and non-response group (FVC <10%). Factors affecting treatment response were evaluated by multivariate logistic regression analysis.RESULTS: A total of 261 patients with iNSIP were enrolled, and 95 patients were followed-up for more than 1 year. Corticosteroid treatment was performed in 86 patients. The treatment group showed a significant improvement in lung function after 1-year: FVC, 10.0%; forced expiratory volume (FEV1), 9.8%; diffusing capacity of the lung for carbon monoxide (DLco), 8.4% (p < 0.001). Sero-negative anti-nuclear antibody (ANA) was significantly related with lung function improvement. Sero-positivity ANA was significantly lower in the response group (p = 0.013), compared to that in the non-response group. A shorter duration of respiratory symptoms at diagnosis was significantly associated with a good response to treatment (p = 0.018).CONCLUSION: Treatment with corticosteroids and/or immunosuppressants improved lung function in iNSIP patients, which was more pronounced in sero-negative ANA and shorter symptom duration patients. These findings suggest that early treatment should be considered in iNSIP patients, even in an early disease stage.
- DOI
- 10.1186/s12931-017-0686-7
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
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