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Ultrasensitive colocalization detection based on plasmonic nanolithography with molecular-overlapped optical near-fields

Title
Ultrasensitive colocalization detection based on plasmonic nanolithography with molecular-overlapped optical near-fields
Authors
Kim K.Lee W.Chung K.Lee H.Son T.Oh Y.Xiao Y.-F.Kim D.H.Kim D.
Ewha Authors
김동하
SCOPUS Author ID
김동하scopus
Issue Date
2018
Journal Title
Progress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN
1605-7422JCR Link
Citation
Progress in Biomedical Optics and Imaging - Proceedings of SPIE vol. 10506
Keywords
biosensorcolocalizationplasmon lithographySurface plasmon resonance
Publisher
SPIE
Indexed
SCOPUS scopus
Document Type
Conference Paper
Abstract
The detection sensitivity of surface plasmon resonance (SPR) biosensors has been improved by employing colocalization of spatial distribution of electromagnetic near-fields and detection molecules. We have used plasmon nanolithography to achieve light-matter colocalization on triangular nanoaperture arrays and optimized array configurations to improve colocalization efficiency. Streptavidin-biotin interactions were measured to validate the concept. It was confirmed that colocalized distributions of target binding and localized near-fields produced larger optical detection sensitivity. The colocalized detection was also shown to come with wider dynamic range than noncolocalized detection. The effective limit-of-detection of colocalized measurements was on the order of 30 pM. The colocalized detection sensitivity was estimated to be below 1 fg/mm2 in a 100-nm deep evanescent area, an enhancement by more than three orders of magnitude over conventional SPR sensor. © 2018 SPIE.
DOI
10.1117/12.2291449
ISBN
9781510614970
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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