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Comparison of unsatisfactory samples from conventional smear versus liquid-based cytology in uterine cervical cancer screening test
- Comparison of unsatisfactory samples from conventional smear versus liquid-based cytology in uterine cervical cancer screening test
- Jeong H.; Hong S.R.; Chae S.-W.; Jin S.-Y.; Yoon H.K.; Lee J.; Kim E.K.; Ha S.T.; Kim S.N.; Park E.-J.; Jung J.J.; Sung S.H.; Lim S.-C.
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- Journal of Pathology and Translational Medicine
- Journal of Pathology and Translational Medicine vol. 51, no. 3, pp. 314 - 319
- Cervical cytology; Conventional smear; Liquid-based cytology; Papanicolaou test; Unsatisfactory
- Seoul National University
- SCOPUS; KCI
- Document Type
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- Background: Cervical cytology for uterine cervical cancer screening has transitioned from conventional smear (CS) to liquid-based cytology (LBC), which has many advantages. The aim of this study was to compare the proportion of unsatisfactory specimens from CS versus LBC at multiple institutions including general hospitals and commercial laboratories. Methods: Each participating institution provided a minimum of 500 Papanicolaou (Pap) test results for analysis. Pap tests were classified according to the participating institution (commercial laboratory or general hospital) and the processing method (CS, ThinPrep, SurePath, or CellPrep). The causes of unsatisfactory results were classified as technical problems, scant cellularity, or complete obscuring factors. Results: A total of 38,956 Pap test results from eight general hospitals and three commercial laboratories were analyzed. The mean unsatisfactory rate of LBC was significantly lower than that of CS (1.26% and 3.31%, p =.018). In the LBC method, samples from general hospitals had lower unsatisfactory rates than those from commercial laboratories (0.65% vs 2.89%, p =.006). The reasons for unsatisfactory results were heterogeneous in CS. On the other hand, 66.2% of unsatisfactory results in LBC were due to the scant cellularity. Conclusions: Unsatisfactory rate of cervical cancer screening test results varies according to the institution and the processing method. LBC has a significantly lower unsatisfactory rate than CS. © 2017 The Korean Society of Pathologists/The Korean Society for Cytopathology.
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