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Implications of Circadian Rhythm in Dopamine and Mood Regulation
- Title
- Implications of Circadian Rhythm in Dopamine and Mood Regulation
- Authors
- Kim, Jeongah; Jang, Sangwon; Choe, Han Kyoung; Chung, Sooyoung; Son, Gi Hoon; Kim, Kyungjin
- Ewha Authors
- 정수영
- SCOPUS Author ID
- 정수영
- Issue Date
- 2017
- Journal Title
- MOLECULES AND CELLS
- ISSN
- 1016-8478
0219-1032
- Citation
- MOLECULES AND CELLS vol. 40, no. 7, pp. 450 - 456
- Keywords
- circadian rhythm; dopaminergic system; mood disorder; Parkinson's disease; REV-ERB alpha
- Publisher
- KOREAN SOC MOLECULAR &
CELLULAR BIOLOGY
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Review
- Abstract
- Mammalian physiology and behavior are regulated by an internal time-keeping system, referred to as circadian rhythm. The circadian timing system has a hierarchical organization composed of the master clock in the suprachiasmatic nucleus (SCN) and local clocks in extra-SCN brain regions and peripheral organs. The circadian clock molecular mechanism involves a network of transcription-translation feedback loops. In addition to the clinical association between circadian rhythm disruption and mood disorders, recent studies have suggested a molecular link between mood regulation and circadian rhythm. Specifically, genetic deletion of the circadian nuclear receptor Rev-erb alpha induces mania-like behavior caused by increased midbrain dopaminergic (DAergic) tone at dusk. The association between circadian rhythm and emotion-related behaviors can be applied to pathological conditions, including neurodegenerative diseases. In Parkinson's disease (PD), DAergic neurons in the substantia nigra pars compacta progressively degenerate leading to motor dysfunction. Patients with PD also exhibit non-motor symptoms, including sleep disorder and neuropsychiatric disorders. Thus, it is important to understand the mechanisms that link the molecular circadian clock and brain machinery in the regulation of emotional behaviors and related midbrain DAergic neuronal circuits in healthy and pathological states. This review summarizes the current literature regarding the association between circadian rhythm and mood regulation from a chronobiological perspective, and may provide insight into therapeutic approaches to target psychiatric symptoms in neurodegenerative diseases involving circadian rhythm dysfunction.
- DOI
- 10.14348/molcells.2017.0065
- Appears in Collections:
- 스크랜튼대학 > 융합학부 > Journal papers
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