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Clinical validation of serum endocan (ESM-1) as a potential biomarker in patients with renal cell carcinoma

Title
Clinical validation of serum endocan (ESM-1) as a potential biomarker in patients with renal cell carcinoma
Authors
Kim K.H.Lee H.H.Yoon Y.E.Na J.C.Kim S.Y.Cho Y.I.Hong S.J.Han W.K.
Ewha Authors
김광현
SCOPUS Author ID
김광현scopusscopus
Issue Date
2018
Journal Title
Oncotarget
ISSN
1949-2553JCR Link
Citation
Oncotarget vol. 9, no. 1, pp. 662 - 667
Keywords
Area under curveCarcinomaEarly diagnosisRenal cell
Publisher
Impact Journals LLC
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
To determine the suitability of serum endocan (ESM-1) levels for diagnosing and monitoring renal cell carcinoma (RCC), we measure serum ESM-1 levels in 56 RCC patients who had undergone radical or partial nephrectomies and 56 age- and sex-matched healthy kidney donors. Measurements were made before and 1 month and 3 months after surgery. The areas under the curve (AUCs) were determined from receiver operating characteristic (ROC) analyses. RCC patients had higher mean serum ESM-1 levels than control subjects (0.59 ± 0.07 vs. 0.52 ± 0.08 ng/mL, P < 0.001), with an AUC of 0.721 (95% CI: 0.628-0.817). In patients with tumors larger than 2 cm (n = 40) and those with clear-cell histology (n = 44), the AUCs for ESM-1 were 0.771 and 0.721, respectively. In control subjects, serum ESM-1 levels were higher in older (> 50 years) individuals (P < 0.001). Among the study cohort, the AUCs for ESM-1 were 0.813 in individuals 50 years of age or younger (n = 55) and 0.637 in individuals older than 50 years (n = 57). In RCC patients, serum ESM-1 levels were reduced 1 month (P = 0.047) and 3 months (P = 0.009) after surgery. These results suggest serum ESM-1 can serve as a serologic biomarker for diagnosing and monitoring RCC, particularly in patients younger than 50 years. © Kim et al.
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DOI
10.18632/oncotarget.23087
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의과대학 > 의학과 > Journal papers
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