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One-pot three component synthesis of 5-allyl-1,2,3-triazoles using copper(i) acetylides

Title
One-pot three component synthesis of 5-allyl-1,2,3-triazoles using copper(i) acetylides
Authors
Reddy P.R.Cui L.Ryu J.-S.
Ewha Authors
류재상
SCOPUS Author ID
류재상scopus
Issue Date
2018
Journal Title
RSC Advances
ISSN
2046-2069JCR Link
Citation
RSC Advances vol. 8, no. 5, pp. 2759 - 2767
Publisher
Royal Society of Chemistry
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
One-pot three-component reactions using copper(i) acetylide, azide, allyl iodide, and NaOH have been developed. The reactions proceed smoothly at room temperature to afford 5-allyl-1,2,3-triazoles, which can be further transformed into a variety of 1,2,3-triazole-fused bi-/tricyclic scaffolds. This method offers the most efficient, convenient, and practical route towards useful polycyclic scaffolds in moderate to excellent yields. © The Royal Society of Chemistry 2018.
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DOI
10.1039/c7ra12889d
Appears in Collections:
약학대학 > 약학과 > Journal papers
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