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Predictors of mortality in Middle East respiratory syndrome (MERS)
- Title
- Predictors of mortality in Middle East respiratory syndrome (MERS)
- Authors
- Hong K.-H.; Choi J.-P.; Hong S.-H.; Lee J.; Kwon J.-S.; Kim S.-M.; Park S.Y.; Rhee J.-Y.; Kim B.-N.; Choi H.J.; Shin E.-C.; Pai H.; Park S.-H.; Kim S.-H.
- Ewha Authors
- 최희정
- SCOPUS Author ID
- 최희정
- Issue Date
- 2018
- Journal Title
- Thorax
- ISSN
- 0040-6376
- Citation
- Thorax vol. 73, no. 3, pp. 286 - 289
- Keywords
- infection control; respiratory infection; viral infection
- Publisher
- BMJ Publishing Group
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- We evaluated the clinical characteristics, cytokine/chemokine concentrations, viral shedding and antibody kinetics in 30 patients with Middle East respiratory syndrome (MERS), including 6 non-survivors admitted to 3 MERS-designated hospitals. Old age, low albumin, altered mentality and high pneumonia severity index score at admission were risk factors for mortality. In addition, severe signs of inflammation at initial presentation (at hospital days 1-4), such as high inducible protein-10 (p=0.0013), monocyte chemoattractant protein-1 (p=0.0007) and interleukin 6 (p=0.0007) concentrations, and poor viral control (high viral load at hospital days 5-10, p<0.001) without adequate antibody titres (low antibody titre at hospital days 11-16, p=0.07) during the course of disease, were associated with mortality. © 2017 author(s).
- DOI
- 10.1136/thoraxjnl-2016-209313
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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