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Seroprevalence of Helicobacter pylori in Korea: A multicenter, nationwide study conducted in 2015 and 2016

Title
Seroprevalence of Helicobacter pylori in Korea: A multicenter, nationwide study conducted in 2015 and 2016
Authors
Lee J.H.Choi K.D.Jung H.-Y.Baik G.H.Park J.K.Kim S.S.Kim B.-W.Hong S.J.Lim H.Shin C.M.Lee S.H.Jeon S.W.Kim J.H.Choi C.W.Jung H.-K.Kim J.-H.Choi S.C.Cho J.W.Lee W.S.Na S.-Y.Sung J.K.Song K.H.Chung J.-W.Yun S.-C.Korean College of Helicobacter and Upper Gastrointestinal Research
Ewha Authors
정혜경
SCOPUS Author ID
정혜경scopus
Issue Date
2018
Journal Title
Helicobacter
ISSN
1083-4389JCR Link
Citation
Helicobacter vol. 23, no. 2
Keywords
Helicobacter pyloriKoreaprevalence
Publisher
Blackwell Publishing Ltd
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Background: The Korean College of Helicobacter and Upper Gastrointestinal Research has studied Helicobacter pylori (H. pylori) prevalence since 1998 and found a dynamic change in its prevalence in Korea. The aim of this study was to determine the recent H. pylori prevalence rate and compare it with that of previous studies according to socioeconomic variables. Methods: We planned to enroll 4920 asymptomatic Korean adults from 21 centers according to the population distribution of seven geographic areas (Seoul, Gyeonggi, Gangwon, Chungcheong, Kyungsang, Cholla, and Jeju). We centrally collected serum and tested H. pylori serum IgG using a chemiluminescent enzyme immunoassay. Results: We analyzed 4917 samples (4917/4920 = 99.9%) from January 2015 to December 2016. After excluding equivocal serologic results, the H. pylori seropositivity rate was 51.0% (2414/4734). We verified a decrease in H. pylori seroprevalence compared with previous studies performed in 1998, 2005, and 2011 (P <.0001). The H. pylori seroprevalence rate differed by area: Cholla (59.5%), Chungcheong (59.2%), Kyungsang (55.1%), Jeju (54.4%), Gangwon (49.1%), Seoul (47.4%), and Gyeonggi (44.6%). The rate was higher in those older than 40 years (38.1% in those aged 30-39 years and 57.7% in those aged 40-49 years) and was lower in city residents than in noncity residents at all ages. Conclusions: Helicobacter pylori seroprevalence in Korea is decreasing and may vary according to population characteristics. This trend should be considered to inform H. pylori-related policies. © 2018 The Authors. Helicobacter Published by John Wiley & Sons Ltd
DOI
10.1111/hel.12463
Appears in Collections:
의과대학 > 의학과 > Journal papers
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