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Validation of prognostic scores to predict short-term mortality in patients with acute-on-chronic liver failure
- Title
- Validation of prognostic scores to predict short-term mortality in patients with acute-on-chronic liver failure
- Authors
- Song D.S.; Kim T.Y.; Kim D.J.; Kim H.Y.; Sinn D.H.; Yoon E.L.; Kim C.W.; Jung Y.K.; Suk K.T.; Lee S.S.; Lee C.H.; Kim T.H.; Choe W.H.; Yim H.J.; Kim S.E.; Baik S.K.; Jang J.Y.; Kim H.S.; Kim S.G.; Yang J.M.; Sohn J.H.; Choi E.H.; Cho H.C.; Jeong S.W.; Kim M.Y.; on behalf of the Korean Acute-on-Chronic Liver Failure (KACLiF) Study Group
- Ewha Authors
- 김태헌; 김태훈
- SCOPUS Author ID
- 김태헌
- Issue Date
- 2018
- Journal Title
- Journal of Gastroenterology and Hepatology (Australia)
- ISSN
- 0815-9319
- Citation
- Journal of Gastroenterology and Hepatology (Australia) vol. 33, no. 4, pp. 900 - 909
- Keywords
- acute-on-chronic liver failure; prognosis; validation
- Publisher
- Blackwell Publishing
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Background and Aim: The aim of this study was to validate the chronic liver failure-sequential organ failure assessment score (CLIF-SOFAs), CLIF consortium organ failure score (CLIF-C OFs), CLIF-C acute-on-chronic liver failure score (CLIF-C ACLFs), and CLIF-C acute decompensation score in Korean chronic liver disease patients with acute deterioration. Methods: Acute-on-chronic liver failure was defined by either the Asian Pacific Association for the study of the Liver ACLF Research Consortium (AARC) or CLIF-C criteria. The diagnostic performances for short-term mortality were compared by the area under the receiver operating characteristic curve. Results: Among a total of 1470 patients, 252 patients were diagnosed with ACLF according to the CLIF-C (197 patients) or AARC definition (95 patients). As the ACLF grades increased, the survival rates became significantly lower. The areas under the receiver operating characteristic of the CLIF-SOFAs, CLIF-C OFs, and CLIF-C ACLFs were significantly higher than those of the Child–Pugh, model for end-stage liver disease, and model for end-stage liver disease-Na scores in ACLF patients according to the CLIF-C definition (all P < 0.05), but there were no significant differences in patients without ACLF or in patients with ACLF according to the AARC definition. The CLIF-SOFAs, CLIF-C OFs, and CLIF-C ACLFs had higher specificities with a fixed sensitivity than liver specific scores in ACLF patients according to the CLIF-C definition, but not in ACLF patients according to the AARC definition. Conclusions: The CLIF-SOFAs, CLIF-C OFs, and CLIF-C ACLFs are useful scoring systems that provide accurate information on prognosis in patients with ACLF according to the CLIF-C definition, but not the AARC definition. © 2017 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd
- DOI
- 10.1111/jgh.13991
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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