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Visual stimulation-induced mild stress enhances cognitive behavior in cynomolgus monkey

Title
Visual stimulation-induced mild stress enhances cognitive behavior in cynomolgus monkey
Authors
Woo D.H.Koh E.H.Shin S.-H.Yang Y.-S.Choe J.C.Lee C.J.Han S.-C.
Ewha Authors
최재천
SCOPUS Author ID
최재천scopusscopus
Issue Date
2018
Journal Title
Scientific Reports
ISSN
2045-2322JCR Link
Citation
Scientific Reports vol. 8, no. 1
Publisher
Nature Publishing Group
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Cortisol is a well-known endogenous glucocorticoid that serves as a stress indicator. It is normally released under stressful condition to warn about imminent danger and thus is critical for survival of the species. However, it is unclear how cortisol relates to cognitive process under physiological condition in high-order primates such as non-human primates (NHP). Here, we report that a slight but significant increase in blood cortisol level by mild stress is positively correlated with the cognitive function in cynomolgus monkey. We stimulated 3 groups of monkeys by viewing consecutive series of pictures of monkeys, pictures of humans, or animation still pictures. We first found that the blood cortisol level was significantly higher during the stimulation session and returned to normal after stimulation session. Among the three types of pictures, the monkeys which were stimulated with monkey pictures showed the most significant increase in cortisol level during stimulation. Furthermore, the monkeys showed significantly enhanced manipulation, suggesting that cortisol affected cognitive processes. Overall, our study demonstrates that visual stimulation both increases blood cortisol and enhances manipulating behavior. Therefore, unlike the common notion that cortisol is a stress indicator, our data supports that a mild increase of cortisol enhances cognition in NHP. © 2018 The Author(s).
DOI
10.1038/s41598-018-22136-9
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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