Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤주영 | * |
dc.contributor.author | K.M.K Swamy | * |
dc.date.accessioned | 2018-11-21T16:30:34Z | - |
dc.date.available | 2018-11-21T16:30:34Z | - |
dc.date.issued | 2018 | * |
dc.identifier.issn | 0925-4005 | * |
dc.identifier.other | OAK-22268 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/246787 | - |
dc.description.abstract | Sensing and monitoring of pH changes in live cells are of great importance for understanding of cellular signaling responses. In this study, we developed a highly sensitive and selective pH sensor, rhodamine-based fluorescence dye 1. The fluorescent emission of 1 at 588 nm increased with the pH decreasing (from pH 7.0–4.0) due to the ring-opening of spirolactam by H+. 1 exhibited good water solubility, high quantum yield, and fast response to pH changes. Moreover, 1 can stain lysosomes in living cells with high photostability and low cytotoxicity. Importantly, 1 was used for monitoring pH changes in lysosomes induced by chloroquine, artesunate and dexamethasone. Therefore, our work provides the potential of probe 1 for visualizing the intracellular changes of pH in clinical and medical applications. © 2018 Elsevier B.V. | * |
dc.description.sponsorship | Korea Basic Science Institute | * |
dc.language | English | * |
dc.publisher | Elsevier B.V. | * |
dc.subject | Cell imaging | * |
dc.subject | Fluorescence | * |
dc.subject | Lysosome | * |
dc.subject | pH sensor | * |
dc.subject | Rhodamine | * |
dc.title | A rhodamine-based fluorescent probe for the detection of lysosomal pH changes in living cells | * |
dc.type | Article | * |
dc.relation.volume | 266 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 416 | * |
dc.relation.lastpage | 421 | * |
dc.relation.journaltitle | Sensors and Actuators, B: Chemical | * |
dc.identifier.doi | 10.1016/j.snb.2018.03.133 | * |
dc.identifier.wosid | WOS:000430274200048 | * |
dc.identifier.scopusid | 2-s2.0-85044607116 | * |
dc.author.google | Lee D. | * |
dc.author.google | Swamy K.M.K. | * |
dc.author.google | Hong J. | * |
dc.author.google | Lee S. | * |
dc.author.google | Yoon J. | * |
dc.contributor.scopusid | 윤주영(7403587371) | * |
dc.contributor.scopusid | K.M.K Swamy(8384468700) | * |
dc.date.modifydate | 20240118162450 | * |