View : 597 Download: 0

Convenient metal-free direct oxidative amidation of aldehyde using dibromoisocyanuric acid under mild conditions

Title
Convenient metal-free direct oxidative amidation of aldehyde using dibromoisocyanuric acid under mild conditions
Authors
Kang, SoosungMinh Thanh LaKim, Hee-Kwon
Ewha Authors
강수성
SCOPUS Author ID
강수성scopus
Issue Date
2018
Journal Title
TETRAHEDRON LETTERS
ISSN
0040-4039JCR Link
Citation
TETRAHEDRON LETTERS vol. 59, no. 39, pp. 3541 - 3546
Keywords
AmidationAldehydesDibromoisocyanuric acidAcyl bromide
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
A facile method for the direct synthesis of amides from aldehydes is described. Amide bonds were synthesized by an oxidative amidation in the presence of dibromoisocyanuric acid (DBI). Treatment of aromatic and aliphatic aldehydes with dibromoisocyanuric acid generated acyl bromide intermediates, which were employed to react with a variety of secondary and primary amines to give amides. Through this reaction method, various amides were synthesized directly from aldehydes under mild conditions in high yields and short times. This facile and efficient procedure provides potential strategy for the direct synthesis of amides from aldehydes. (C) 2018 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.tetlet.2018.08.026
Appears in Collections:
약학대학 > 약학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

BROWSE