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dc.contributor.author성순희-
dc.contributor.author문병인-
dc.contributor.author조민선-
dc.contributor.author임우성-
dc.contributor.author박상희-
dc.date.accessioned2018-11-21T16:30:07Z-
dc.date.available2018-11-21T16:30:07Z-
dc.date.issued2018-
dc.identifier.issn1526-8209-
dc.identifier.issn1938-0666-
dc.identifier.otherOAK-23387-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/246641-
dc.description.abstractUsing the 7 immunohistochemical surrogate markers, we tried to classify 200 TNBCs into 4 molecular subtypes; luminal androgen receptor, mesenchymal, basal-like immune-activated, and basal-like immune-suppressive types. Our results showed that each subtype had significant differences in clinicopathological characteristics and prognosis. Introduction: Recently, Burstein et al identified 4 stable molecular subtypes of triple negative breast cancer (TNBC) by mRNA profiling: luminal androgen receptor (LAR), mesenchymal (MES), basal-like immune-activated (BLIA), and basallike immune-suppressive (BLIS) types. The purpose of this study was to assess the feasibility of immunohistochemistry (IHC) surrogate panel in classifying the TNBC molecular subtypes using a large cohort of TNBC retrieved from a single institution. Materials and Methods: IHC for androgen receptor [AR], claudin-3, E-cadherin, cytokeratin 5/6 [CK5/6], epidermal growth factor receptor [EGFR], indoleamine 2,3-dioxygenase 1 [IDO1], and Forkhead box C1 [FOXC1] were performed using the tissue microarray constructed from 200 TNBC samples. Results: The 200 TNBCs were classified as LAR (AR(+), n = 22; 11.0%), MES (claudin 3(-) and/or E-cadherin(-), n = 23; 11.5%), basal-like (CK5/6(+) and/or EGFR(+), n = 85; 42.5%), mixed (n = 60; 30%), and unclassifiable type (n = 10; 5%). LAR type was associated with older patient age, apocrine histologic features, low density of stromal tumor-infiltrating lymphocytes (TIL), and low Ki-67 labeling index. MES type was associated with tumor cell discohesiveness and metaplastic features. Basal-like type was associated with younger patient age, high histologic grade, high stromal TIL density, and high Ki-67 labeling index. Basal-like TNBCs were further classified as BLIA (IDO1(+) and FOXC1(+), n = 27) or BLIS type (IDO1-and FOXC1(+), n = 11). BLIS type was associated with large tumor size and low stromal TIL density, which had the worst prognostic outcome among 4 subtypes. Conclusion: The IHC surrogate panel may define TNBC subtypes with distinct clinicopathologic characteristics and prognostic significance.-
dc.languageEnglish-
dc.publisherCIG MEDIA GROUP, LP-
dc.subjectBasal-like immune-activated-
dc.subjectBasal-like immune-suppressed-
dc.subjectImmunohistochemistry-
dc.subjectMolecular subtype-
dc.subjectTriple negative breast carcinoma-
dc.titleFeasibility of Classification of Triple Negative Breast Cancer by Immunohistochemical Surrogate Markers-
dc.typeArticle-
dc.relation.issue5-
dc.relation.volume18-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpageE1123-
dc.relation.lastpageE1132-
dc.relation.journaltitleCLINICAL BREAST CANCER-
dc.identifier.doi10.1016/j.clbc.2018.03.012-
dc.identifier.wosidWOS:000445702400052-
dc.identifier.scopusid2-s2.0-85046851065-
dc.author.googleKim, Sewha-
dc.author.googleMoon, Byung-In-
dc.author.googleLim, Woosung-
dc.author.googlePark, Sanghui-
dc.author.googleCho, Min Sun-
dc.author.googleSung, Sun Hee-
dc.contributor.scopusid성순희(7202731948)-
dc.contributor.scopusid문병인(7101878644)-
dc.contributor.scopusid조민선(13205279200)-
dc.contributor.scopusid임우성(27167744500)-
dc.contributor.scopusid박상희(12041890800)-
dc.date.modifydate20210915163347-
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의과대학 > 의학과 > Journal papers
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