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Development of mRNA vaccines and their prophylactic and therapeutic applications

Title
Development of mRNA vaccines and their prophylactic and therapeutic applications
Authors
Lee, KyuriKim, MinjeongSeo, YunmiLee, Hyukjin
Ewha Authors
이혁진이규리김민정
SCOPUS Author ID
이혁진scopus; 김민정scopusscopus
Issue Date
2018
Journal Title
NANO RESEARCH
ISSN
1998-0124JCR Link

1998-0000JCR Link
Citation
NANO RESEARCH vol. 11, no. 10, pp. 5173 - 5192
Keywords
messenger RNA (mRNA) vaccinesprophylactic vaccinesself-amplifying mRNA vaccinestherapeutic vaccinecancer immunotherapy
Publisher
TSINGHUA UNIV PRESS
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Review
Abstract
Nucleic acid vaccines have attracted enormous attention for resolving the limitations of conventional vaccines using live attenuated viruses. Because nucleic acid vaccines can be produced rapidly in response to the emergence of new virus strains, they are more appropriate for the control of urgent epidemic and pandemic issues. In particular, messenger RNA (mRNA) vaccines have evolved as a new type of nucleic acid vaccines in accordance with their superior protein expression and a lack of mutagenesis as compared with DNA vaccines. Using mRNA vaccines, large amounts of target proteins can be expressed in immune cells for efficient immunization. For instance, antigen-specific vaccination is a feasible option involving the expression of specific antigens in antigen-presenting cells. Immunological reactions are modulated by expressing several proteins associated with stimulation or maturation of immune cells. In addition, mRNA vaccines can stimulate innate immunity through specific recognition by pattern recognition receptors. On the basis of these remarkable properties, mRNA vaccines have been used for prophylactic and therapeutic applications. This review highlights the role of mRNA vaccines as prophylactic vaccines for prevention of future infections and as therapeutic vaccines for cancer immunotherapy. In addition to the conventional type of mRNA vaccines, RNA replicons (self-amplifying mRNA vaccines) will be described.
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DOI
10.1007/s12274-018-2095-8
Appears in Collections:
약학대학 > 약학과 > Journal papers
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