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dc.contributor.author김대기-
dc.date.accessioned2018-11-16T16:30:04Z-
dc.date.available2018-11-16T16:30:04Z-
dc.date.issued2018-
dc.identifier.issn0039-6060-
dc.identifier.otherOAK-23525-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/246531-
dc.description.abstractBackground: EW-7197 is an oral transforming growth factor beta type I receptor kinase inhibitor currently undergoing phase I clinical trials for cancer treatment in the United States. This study evaluates whether EW-7197 prevents peritoneal adhesion formation in a rat model. Methods: Forty-eight female Wistar rats underwent peritoneal adhesion induction by the creation of peritoneal ischemic buttons and were randomly divided into 4 groups of 12 each. The control group received 0.3 mL vehicle by oral gavage once daily for 7 days after adhesion induction. The 10 mg and 20 mg groups received 10 or 20 mg/kg EW-7197 phosphate dissolved in 0.3 mL vehicle by oral gavage once daily for 7 days after adhesion induction. The rebound group received 20 mg/kg EW-7197 phosphate dissolved in 0.3 mL vehicle by oral gavage once daily for 7 days after adhesion induction followed by 0.3 mL vehicle only by gavage once daily for an additional 21 days. After the respective treatments were completed, the animals were euthanized. Results: All rats survived until the end of the study without complications. EW-7197 reduced the incidence, quality, and tenacity of peritoneal adhesions in a dose-dependent manner. Fibrosis and collagen production were reduced in EW-7197-treated peritoneal ischemic buttons. Transforming growth factor beta i/Smad2/3 signaling and mesothelial-to-mesenchymal transition were inhibited in EW-7197-treated peritoneal ischemic buttons. Discontinuation of EW-7197 was not associated with rebound effects. Conclusion: EW-7197 prevented peritoneal adhesion formation potentially via inhibition of transforming growth factor beta 1/Smad2/3-induced mesothelial-to-mesenchymal transition in a rat model. (C) 2018 Elsevier Inc. All rights reserved.-
dc.languageEnglish-
dc.publisherMOSBY-ELSEVIER-
dc.titleEW-7197, an oral transforming growth factor beta type I receptor kinase inhibitor, for preventing peritoneal adhesion formation in a rat model-
dc.typeArticle-
dc.relation.issue5-
dc.relation.volume164-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage1100-
dc.relation.lastpage1108-
dc.relation.journaltitleSURGERY-
dc.identifier.doi10.1016/j.surg.2018.07.005-
dc.identifier.wosidWOS:000448761400029-
dc.identifier.scopusid2-s2.0-85054142097-
dc.author.googleTsauo, Jiaywei-
dc.author.googleSong, Ho-Young-
dc.author.googleChoi, Eun Young-
dc.author.googleKim, Dae-Kee-
dc.author.googleKim, Kun Yung-
dc.author.googlePark, Jung-Hoon-
dc.author.googleKim, Min Tae-
dc.author.googleYoon, Sung Hwan-
dc.author.googleLim, Young Je-
dc.contributor.scopusid김대기(35083694200)-
dc.date.modifydate20210915131220-
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약학대학 > 약학과 > Journal papers
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