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Mesenchymal stem cell-driven activatable photosensitizers for precision photodynamic oncotherapy

Title
Mesenchymal stem cell-driven activatable photosensitizers for precision photodynamic oncotherapy
Authors
Li, XingshuKim, C-yoonShin, Jeong MinLee, DayoungKim, GyoungmiChung, Hyung-MinHong, Ki-SungYoon, Juyoung
Ewha Authors
윤주영
SCOPUS Author ID
윤주영scopus
Issue Date
2018
Journal Title
BIOMATERIALS
ISSN
0142-9612JCR Link

1878-5905JCR Link
Citation
BIOMATERIALS vol. 187, pp. 18 - 26
Keywords
Photodynamic therapyMesenchymal stem cellsTumor targetingActivatable photosensitizerPrecision medicine
Publisher
ELSEVIER SCI LTD
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Precise targeting with minimal side effects is of particular interest for personalized medicine, although it remains a challenge. Herein, we demonstrate precision photodynamic therapy (PDT) utilizing human mesenchymal stem cells (MSCs) as cellular vehicles to deliver a new activatable photosensitizer (PcS). In vivo real-time optical imaging tests indicated that PcS-loaded MSCs possess excellent tumor-homing properties. More importantly, dye transfer assays confirm that MSCs precisely transfer PcS into human colon cancer cells (HCT116) via the "bystander effect." Upon localized light irradiation, the growth of intraperitoneal xenograft tumors was significantly inhibited by the photodynamic effect. These findings represent a promising strategy for precise oncotherapy.
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DOI
10.1016/j.biomaterials.2018.09.041
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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