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The Fat Mass- and Obesity-Associated (FTO) Gene to Obesity: Lessons from Mouse Models
- Title
- The Fat Mass- and Obesity-Associated (FTO) Gene to Obesity: Lessons from Mouse Models
- Authors
- Chang, Jeong Yoon; Park, Joo Hyun; Park, Sung Eun; Shon, Jinyoung; Park, Yoon Jung
- Ewha Authors
- 박윤정
- SCOPUS Author ID
- 박윤정
- Issue Date
- 2018
- Journal Title
- OBESITY
- ISSN
- 1930-7381
1930-739X
- Citation
- OBESITY vol. 26, no. 11, pp. 1674 - 1686
- Publisher
- WILEY
- Indexed
- SCIE; SCOPUS
- Document Type
- Review
- Abstract
- ObjectiveMethodsGenetic variants at the fat mass- and obesity-associated (FTO) locus are strongly associated with obesity-related traits by regulating neighboring genes. Nevertheless, it is possible that FTO protein is directly involved in mechanisms regulating body composition and adiposity. Here, the in vivo biological functions of FTO in the risk for obesity were studied by reviewing murine models. The effects of the locus-specific manipulations of the murine Fto gene on metabolic-related phenotypes in genetically modified mouse models were reviewed and summarized into the following three categories: growth and body composition, eating behaviors, and metabolic homeostasis. ResultsConclusionsThe mouse models showed different phenotypes depending on target tissues and methods for gene manipulation. Mice harboring deletions or point mutations at the Fto locus had high metabolic rates, while FTO-overexpressing mice showed dyslipidemia. Both deletion and overexpression of the Fto gene led to abnormal eating behaviors. Intriguingly, several phenotypes were differently expressed depending on developmental timing of the genetic manipulations. For instance, a germ line deletion decreased total body fat mass, while the deletion in adult mice increased it. The results highlight that FTO is critical not only for body composition but also normal development, and its function might differ depending on the stage of development.
- DOI
- 10.1002/oby.22301
- Appears in Collections:
- 신산업융합대학 > 식품영양학과 > Journal papers
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