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The Fat Mass- and Obesity-Associated (FTO) Gene to Obesity: Lessons from Mouse Models

Title
The Fat Mass- and Obesity-Associated (FTO) Gene to Obesity: Lessons from Mouse Models
Authors
Chang, Jeong YoonPark, Joo HyunPark, Sung EunShon, JinyoungPark, Yoon Jung
Ewha Authors
박윤정
SCOPUS Author ID
박윤정scopus
Issue Date
2018
Journal Title
OBESITY
ISSN
1930-7381JCR Link

1930-739XJCR Link
Citation
OBESITY vol. 26, no. 11, pp. 1674 - 1686
Publisher
WILEY
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Review
Abstract
ObjectiveMethodsGenetic variants at the fat mass- and obesity-associated (FTO) locus are strongly associated with obesity-related traits by regulating neighboring genes. Nevertheless, it is possible that FTO protein is directly involved in mechanisms regulating body composition and adiposity. Here, the in vivo biological functions of FTO in the risk for obesity were studied by reviewing murine models. The effects of the locus-specific manipulations of the murine Fto gene on metabolic-related phenotypes in genetically modified mouse models were reviewed and summarized into the following three categories: growth and body composition, eating behaviors, and metabolic homeostasis. ResultsConclusionsThe mouse models showed different phenotypes depending on target tissues and methods for gene manipulation. Mice harboring deletions or point mutations at the Fto locus had high metabolic rates, while FTO-overexpressing mice showed dyslipidemia. Both deletion and overexpression of the Fto gene led to abnormal eating behaviors. Intriguingly, several phenotypes were differently expressed depending on developmental timing of the genetic manipulations. For instance, a germ line deletion decreased total body fat mass, while the deletion in adult mice increased it. The results highlight that FTO is critical not only for body composition but also normal development, and its function might differ depending on the stage of development.
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DOI
10.1002/oby.22301
Appears in Collections:
신산업융합대학 > 식품영양학과 > Journal papers
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