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자연과학대학
화학·나노과학전공
Journal papers
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Solvent-free preparation of caprolactone oligomer microspheres
Title
Solvent-free preparation of caprolactone oligomer microspheres
Authors
Lee J.
;
Oh S.
;
Joo M.K.
;
Jeong B.
Ewha Authors
정병문
SCOPUS Author ID
정병문
Issue Date
2008
Journal Title
Journal of Physics and Chemistry of Solids
ISSN
0022-3697
Citation
Journal of Physics and Chemistry of Solids vol. 69, no. 41400, pp. 1596 - 1599
Indexed
SCI; SCIE; SCOPUS
Document Type
Article
Abstract
Caprolactone (Mn∼3000 Da, melting point ∼46 °C) oligomer microspheres were prepared by an organic solvent-free process, and were investigated as a delivery system of a hydrophobic model drug (estradiol). The drug was dissolved in a polycaprolactone/poly(ethylene glycol-b-caprolactone) mixture at 50 °C, which was above the melting points of both polymers. The mixture was homogenized in water for 10 min at 50 °C, then it was quenched in the ice bath for 10 min to harden the microsphere. The polycaprolactone of the poly(ethylene glycol-b-caprolactone) coaggregated into the microsphere, and poly(ethylene glycol) formed a shell layer of the microsphere that protects the microsphere from interparticle aggregation during the hardening process of the microsphere in water. The size of microsphere could be controlled by the amount of polycaprolactone relative to poly(ethylene glycol-b-caprolactone). Estradiol release from the microsphere was investigated. © 2007 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.jpcs.2007.09.016
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