View : 182 Download: 0

Changes in plasma and urine endothelin levels during acute exacerbation of asthma

Changes in plasma and urine endothelin levels during acute exacerbation of asthma
Chang J.H.Tae Rim ShinGa Eun WooJong Seon KimEun Soon HongGi Yeoul SeoJoo Hyun ChaMi Seon KimYeung Seon KimYoung Joo Cho
Ewha Authors
조영주scopus; 장중현scopus
Issue Date
Journal Title
Tuberculosis and Respiratory Diseases
0378-0066JCR Link
Tuberculosis and Respiratory Diseases vol. 44, no. 4, pp. 844 - 852
SCOPUS scopus
Document Type
Background: Recent studies have documented increased release of endothelin(ET) during acute attack of asthma. The purpose of this study is to observe the link between plasma level and urinary excretion of each and changes during acute exacerbation. Method: Plasma and 24 hour urine were collected from sixteen asthmatics during acute exacerbation, twice; first day of symptomatic exacerbation and two weeks after treatment. Controls were ten healthy normal subjects. All patients were treated with corticosteroid and beta-2 adrenergic agonist on admission. ET was determined by radioimmunoassay and had 100% cross reactivity with ET-1, 67% with ET-2, 84% with ET-3, and 8% with Big-ET. Results: Plasma ETs were significantly elevated during acute attack of asthma compared with those in remission and controls. However, there was no significant changes in urine ET concentrations or total ET amounts in 24 hour urine during exacerbation up to two weeks. Those levels of urine ET in asthmatics were still higher than controls. ET concentrations in plasma or urine were not correlated with pulmonary functional parameters and hypoxemia. Conclusion: The findings suggests that increased plasma ETs are related with exaggerated release during acute asthma. Urinary ET excretion is increased in asthma. However, urine ET changes during exacerbation should be observed in a larger and longer scale.
Show the fulltext
Appears in Collections:
의과대학 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
RIS (EndNote)
XLS (Excel)


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.