View : 257 Download: 64

Full metadata record

DC Field Value Language
dc.contributor.author한운섭-
dc.contributor.author박응범-
dc.contributor.author김광호-
dc.contributor.author이선영-
dc.date.accessioned2018-06-02T08:15:02Z-
dc.date.available2018-06-02T08:15:02Z-
dc.date.issued1998-
dc.identifier.issn1011-8934-
dc.identifier.otherOAK-17084-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/244369-
dc.description.abstractWe have examined the serum levels of the mutant p53 protein in patients with colorectal cancer preoperatively (n=50), and in patients with adenomatous polyp (n=13). Mutant p53 protein in patients after curative surgical resection of colorectal cancer (n=26, part of the fifty preoperative patients) was also measured. Serum samples were stored frozen at -70°C until the time of analysis. We used the p53 mutant ELISA (QIA03, CALBIOCHEM) system. Serum levels of the mutant p53 protein in patients with colorectal cancer (mean=0.97±0.14 ng/ml, ranged from 0.7 ng/ml to 1.37 ng/ml, n=50) were significantly greater than those in patients with adenomatous polyp (mean=0.73±0.06 ng/ml, ranged from 0.69 ng/ml to 0.83 ng/ml) (p<0.001). There was a significant correlation between serum p53 levels and CA19-9 levels (p<0.01). Serum levels of the mutant p53 protein prior to surgery (mean=0.97±0.13 ng/ml, n=26) significantly decreased after surgical resection of tumor (mean=0.82±0.07 ng/ml) (p<0.001, paired t-test). These results suggest that mutant p53 protein might be used as a potential biomarker in the management of patients with colorectal cancer. Further study is warranted to establish its clinical significance. Copyright © The Korean Academy of Medical Sciences.-
dc.languageEnglish-
dc.titleIncreased serum levels of mutant p53 proteins in patients with colorectal cancer-
dc.typeArticle-
dc.relation.issue1-
dc.relation.volume13-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.indexKCI-
dc.relation.startpage44-
dc.relation.lastpage48-
dc.relation.journaltitleJournal of Korean Medical Science-
dc.identifier.scopusid2-s2.0-0031992945-
dc.author.googleShim K.-S.-
dc.author.googleKim K.-H.-
dc.author.googlePark B.-W.-
dc.author.googleLee S.-Y.-
dc.author.googleChoi J.-H.-
dc.author.googleHan W.-S.-
dc.author.googlePark E.-B.-
dc.contributor.scopusid한운섭(7401899962;24172227800)-
dc.contributor.scopusid박응범(56059292000)-
dc.contributor.scopusid김광호(57192983544;57189050414)-
dc.contributor.scopusid이선영(7201404669)-
dc.date.modifydate20210915112823-


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE