Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 유충규 | - |
dc.date.accessioned | 2018-06-02T08:14:56Z | - |
dc.date.available | 2018-06-02T08:14:56Z | - |
dc.date.issued | 2000 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.other | OAK-17168 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/244327 | - |
dc.description.abstract | 6-Arylamino-7-halo-5,8-quinolinediones (4a-4k, 5a-5b) were tested for in vitro cytotoxicity against human solid tumor cell lines such as A 549 (non-small cell lung), SK-OV-3 (ovarian), SK-MEL-2 (melanoma), HCT-15 (colon) and XF 498 (CNS) by SRB assay. The arylamino-7-chloro-5,8-quinolinediones 4 were also evaluated for cyclin-dependent kinase (CDK2 and CDK4) inhibitory effect. Among them, the 5,8-quinolinediones 4a and 5a with 7-(4-fluorophenyl)amino group were found to be potent cytotoxic against HCT 15, SKOV-3 and XF 498, and the compounds 4f and 4i showed inhibitory activities for the CDK4. | - |
dc.language | English | - |
dc.title | Cytotoxic activities of 6-arylamino-7-halo-5,8-quinolinediones against human tumor cell lines. | - |
dc.type | Article | - |
dc.relation.issue | 1 | - |
dc.relation.volume | 23 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.index | KCI | - |
dc.relation.startpage | 42 | - |
dc.relation.lastpage | 45 | - |
dc.relation.journaltitle | Archives of Pharmacal Research | - |
dc.identifier.scopusid | 2-s2.0-0034137304 | - |
dc.author.google | Ryu C.K. | - |
dc.author.google | Kang H.Y. | - |
dc.author.google | Yi Y.J. | - |
dc.author.google | Lee C.O. | - |
dc.contributor.scopusid | 유충규(15846918400) | - |
dc.date.modifydate | 20180601110730 | - |