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Glucose/oxygen deprivation induces release of [3H]5-hydroxytryptamine associated with synapsin 1 expression in rat hippocampal slices
- Title
- Glucose/oxygen deprivation induces release of [3H]5-hydroxytryptamine associated with synapsin 1 expression in rat hippocampal slices
- Authors
- Park E.; Sang Hui Chu; Lee K.
- Ewha Authors
- 이경은; 박은미
- SCOPUS Author ID
- 이경은; 박은미
- Issue Date
- 2000
- Journal Title
- Korean Journal of Physiology and Pharmacology
- ISSN
- 1226-4512
- Citation
- Korean Journal of Physiology and Pharmacology vol. 4, no. 5, pp. 347 - 353
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Article
- Abstract
- It has been well documented that a massive release of not only glutamate but also other neurotransmitters may modulate the final responses of nerve cells to the ischemic neuronal injury. But there is no information regarding whether the release of monoamines is directly associated with synaptic vesicular proteins under ischemia. In the present study, it was investigated whether synapsin 1, syntaxin and SNAP-25 are involved in the release of 5-hydroxytryptamine ([3H]5-HT) in glucose/oxygen deprived (GOD) rat hippocampal slices. And, the effect of NMDA receptor using DL-2-amino-5-phosphonovaleric acid (APV) on ischemia-induced release of 5-HT and the changes of the above proteins were also investigated. GOD for 20 minutes enhanced release of [3H]5-HT, which was in part blocked by the NMDA receptor antagonist, APV. The augmented expression of synapsin 1 during GOD for 20 minutes, which was also in part prevented by APV. In contrast, the expression of syntaxin and SNAP-25 were not altered during GOD. These results suggest that ischemic insult induces release of [3H]5-HT associated with synapsin 1, synaptic vesicular protein, via activation of NMDA receptor in part.
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- 의과대학 > 의학과 > Journal papers
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