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Evaluation of cytotoxic potential of indonesian medicinal plants in cultured human cancer cells

Title
Evaluation of cytotoxic potential of indonesian medicinal plants in cultured human cancer cells
Authors
Park G.Lee E.-J.Min H.-Y.Choi H.-Y.Han A.-R.Lee S.K.Seo E.-K.
Ewha Authors
이상국서은경한아름
SCOPUS Author ID
서은경scopus; 한아름scopus
Issue Date
2002
Journal Title
Natural Product Sciences
ISSN
1226-3907JCR Link
Citation
Natural Product Sciences vol. 8, no. 4, pp. 165 - 169
Indexed
SCOPUS; KCI scopus
Document Type
Article
Abstract
One-hundred and twenty plant extracts were prepared from 29 cIndonesian plants and were primarily tested in vitro cytotoxicity in cultured human lung (A549), colon (Col2), and stomach (SNU-638) cancer cells. As a result, the 23 extracts were found to be active in the criteria of ED50<20 μg/ml. Remarkable cytotoxicity was observed for chloroform and n-butanol extracts of Calotropis gigantea, with ED50 values ranging from 0.25 to 0.46 μg/ml. Five extracts derived from Eclipta alba and Excoecaria cochinchinensis displayed potent cell-line selective cytotoxicity, while the rest of 15 extracts showed modest cytotoxic activity against all of three cancer cells. In addition, the cytotoxic potential of subfractions of Zingiber cassumunar against a panel of human cancer cell lines is presented.
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