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Evaluation of DNA strand-scission activity of the Korean indigenous plants

Title
Evaluation of DNA strand-scission activity of the Korean indigenous plants
Authors
Choi H.-Y.Han A.-R.Mar W.Seo E.-K.
Ewha Authors
서은경한아름
SCOPUS Author ID
서은경scopus; 한아름scopus
Issue Date
2002
Journal Title
Natural Product Sciences
ISSN
1226-3907JCR Link
Citation
Natural Product Sciences vol. 8, no. 4, pp. 162 - 164
Indexed
SCOPUS; KCI scopus
Document Type
Article
Abstract
The methanol extracts of 42 Korean indigenous plants were evaluated for the DNA strand-scission activity. As a result, the 17 extracts were found to be active in the criteria of IC50<25 μg/ml. Among others, the MeOH extracts of Caesalpinia sappan and Mucuna birdwoodiana showed the most potent DNA strand-scission activity with IC50 values of 5.9 and 4.9 μg/ml, respectively. Therefore, the partition and fractionation for C. sappan were performed and tested in the DNA strand-scission assay system for further bioassay-guided fractionation.
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약학대학 > 약학과 > Journal papers
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