Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 박혜영 | * |
dc.date.accessioned | 2018-06-02T08:14:30Z | - |
dc.date.available | 2018-06-02T08:14:30Z | - |
dc.date.issued | 1996 | * |
dc.identifier.issn | 1016-8478 | * |
dc.identifier.other | OAK-17499 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/244158 | - |
dc.description.abstract | We have used both quantitative autoradiography to localize in rat brain beta-1 and beta-2 adrenergic receptors and in situ hybridization to detect expression of beta-1 adrenergic receptor mRNA in rat brain. The receptors were labeled in vitro with 3H-dihydroalprenolol (3H-DIIA) that binds nonselectively to both beta-1 and beta-2 receptor subtypes. Selective inhibition of 3H-DHA binding with specific antagonists of beta-1 and beta-2 receptors allowed the visualization of beta-adrenergic receptor subtypes. High levels of beta-1 receptors were observed in the cingulate cortex, layers I-III of the cerebral cortex, hippocampus, and thalamus. Oligonucleotide labeled with 35S-dATP was used for in situ hybridization. High levels of beta-2 receptors were found in the cerebellum. Approximately equal levels of beta-1 and beta-2 receptors occurred in the midbrain including substantia nigra. The hybridization signal for beta-1 mRNA was strongest in cingulate and piriform cortex, thalamic nuclei and light or moderate in somatosensory cortex and hippocampus. The pronounced differences in the ratio of beta-1 to beta-2 receptors among brain .regions suggests that the subtypes of beta-adrenergic receptors may play different roles in neuronal function. © 1996 The Korean Society for Molecular Biology. | * |
dc.language | English | * |
dc.title | Quantitative autoradiography of beta-1 and beta-2 adrenergic receptor and cellular localization of mRNA for beta-1 adrenergic receptor in rat brain | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 6 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 456 | * |
dc.relation.lastpage | 462 | * |
dc.relation.journaltitle | Molecules and Cells | * |
dc.identifier.scopusid | 2-s2.0-21944448860 | * |
dc.author.google | Park H.-Y. | * |
dc.author.google | Park K.-H. | * |
dc.author.google | Kim Y.-S. | * |
dc.author.google | Shin S.-G. | * |
dc.author.google | Chung M.-H. | * |
dc.author.google | Park C.-W. | * |
dc.contributor.scopusid | 박혜영(7601567979) | * |
dc.date.modifydate | 20240301081003 | * |