Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 강은숙 | - |
dc.date.accessioned | 2018-06-02T08:14:19Z | - |
dc.date.available | 2018-06-02T08:14:19Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.other | OAK-17615 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/244081 | - |
dc.description.abstract | Induction of molecular chimerism following reconstitution of mice with auiologous bone marrow cells expressing a retrovirally encoded allogeneic MHC class I Ag results in donor-specific tolerance. To investigate the mechanism by which CD4 T cells that recognize allogeneic MHC class I through the indirect pathway of Ag presentation are rendered tolerant in molecular chimeras, transgenic mice expressing a TCR on CD4 T cells specific for peptides derived from Kb were used. CD4 T cells expressing the transgenic TCR were detected in mice reconstituted with bone marrow cells transduced with retroviruses carrying the gene encoding H-2Kb, albeit detection was at lower levels than in mice receiving mock-transduced bone marrow. Despite the presence of CD4 T cells expressing an alloreactive TCR, mice receiving H-2K b-transduced bone marrow permanently accepted Kb disparate skin grafts. CD4+CD25+ T cells from mice reconstituted with H-2Kb-transduced bone marrow prevented rejection of K b disparate skin grafts when adoptively transferred into immunodeficient mice along with effector T cells, suggesting that induction of molecular chimerism leads to the generation of donor specific regulatory T cells, which may be involved in preventing alloreactive CD4 T cell responses that lead to rejection. Copyright © 2006 by The American Association of Immunologists, Inc. | - |
dc.language | English | - |
dc.title | Induction of alloreactive CD4 T cell tolerance in molecular chimeras: A possible role for regulatory T cells | - |
dc.type | Article | - |
dc.relation.issue | 6 | - |
dc.relation.volume | 176 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 3410 | - |
dc.relation.lastpage | 3416 | - |
dc.relation.journaltitle | Journal of Immunology | - |
dc.identifier.scopusid | 2-s2.0-33644847664 | - |
dc.author.google | Forman D. | - |
dc.author.google | Kang E.-S. | - |
dc.author.google | Tian C. | - |
dc.author.google | Paez-Cortez J. | - |
dc.author.google | Iacomini J. | - |
dc.date.modifydate | 20200911081002 | - |