Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박시훈 | * |
dc.contributor.author | 권기환 | * |
dc.date.accessioned | 2018-06-02T08:14:00Z | - |
dc.date.available | 2018-06-02T08:14:00Z | - |
dc.date.issued | 2007 | * |
dc.identifier.issn | 1738-5520 | * |
dc.identifier.other | OAK-17814 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/243957 | - |
dc.description.abstract | Background and Objectives : Previous studies have demonstrated that adipokines can have positive and/or negative effects on vascular function. In this study, we attempted to characterize the association of adipokines with endothelium-dependent vasodilation in healthy premenopausal women. Subjects and Methods : Noninvasive pulse wave analysis coupled with provocative pharmacological testing with salbutamol was used to measure endothelium- dependent vasodilation in 60 healthy premenopausal women [37 obese women; body mass index (BMI) > 25 kg/m2, 23 age-matched non-obese women; BMI<25 kg/m2]. The lipid profile, fasting insulin, glucose, and C-reactive protein (CRP) concentrations in each patient were assessed via standard laboratory techniques, and plasma concentrations of various adipokines, such as adiponectin, leptin, resistin and TNF-α, were measured via enzyme immunoassays. Results : In the obese group, higher leptin concentrations were significantly associated with impairments in endothelium-dependent vasodilation (r=-0.371, p=0.005). This association remained significant, even after adjustment for other risk factors (β3=-0.39, p=0.006). However, we determined that there was no significant correlation between endothelium-dependent vasodilation and these variables in the obese group and the control group. Conclusion : Increased plasma concentration of leptin was associated with impairment in endothelial function in obese premenopausal women, regardless of the metabolic and inflammatory disturbances associated with obesity. © 2007, The Korean Society of Circulation. | * |
dc.language | English | * |
dc.title | Leptin is associated with endothelial dysfunction in healthy obese premenopausal women | * |
dc.type | Article | * |
dc.relation.issue | 6 | * |
dc.relation.volume | 37 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 251 | * |
dc.relation.lastpage | 257 | * |
dc.relation.journaltitle | Korean Circulation Journal | * |
dc.identifier.scopusid | 2-s2.0-34447338056 | * |
dc.author.google | Kwon K. | * |
dc.author.google | Choi K. | * |
dc.author.google | Park S.-H. | * |
dc.contributor.scopusid | 박시훈(9737584900;57191750840) | * |
dc.contributor.scopusid | 권기환(57203037966) | * |
dc.date.modifydate | 20240118164632 | * |