Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이수영 | * |
dc.date.accessioned | 2018-05-30T08:14:21Z | - |
dc.date.available | 2018-05-30T08:14:21Z | - |
dc.date.issued | 2006 | * |
dc.identifier.issn | 0300-8177 | * |
dc.identifier.other | OAK-3045 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/243609 | - |
dc.description.abstract | Signaling by tumor necrosis factor (TNF)-related activation-induced cytokine (TRANCE) is essential for the differentiation of monocytes/ macrophages into osteoclasts. We show here that TRANCE selectively activates Rac1, but not Rac2 in osteoclast precursors. Expression of a dominant interfering mutant of TNF receptor-associated factor (TRAF)6 blocks TRANCE-mediated Rac1 activation, indicating that Rac1 lies downstream of TRAF6. Osteoclast precursors expressing a dominant negative Rac1N17 are defective in TRANCE-induced IKK activation and IκBα degradation resulting in inhibition of NFκB-dependent reporter gene activity. In addition, Rac1 acts upstream of TAK1 to induce NF-κB activation and is required for the normal differentiation of osteoclast precursors. Thus, Rac1 may represent a key regulator for differentiation of osteoclasts through the activation of NF-κB. © Springer Science + Business Media, Inc. 2006. | * |
dc.language | English | * |
dc.title | Rac1 GTPase regulates osteoclast differentiation through TRANCE-induced NF-κB activation | * |
dc.type | Article | * |
dc.relation.issue | 1-2 | * |
dc.relation.volume | 281 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 55 | * |
dc.relation.lastpage | 61 | * |
dc.relation.journaltitle | Molecular and Cellular Biochemistry | * |
dc.identifier.doi | 10.1007/s11010-006-0333-y | * |
dc.identifier.wosid | WOS:000233738200006 | * |
dc.identifier.scopusid | 2-s2.0-29944435017 | * |
dc.author.google | Lee N.K. | * |
dc.author.google | Choi H.K. | * |
dc.author.google | Kim D.-K. | * |
dc.author.google | Lee S.Y. | * |
dc.contributor.scopusid | 이수영(53980218900;7409697278) | * |
dc.date.modifydate | 20240415140424 | * |