Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 김원기 | - |
dc.date.accessioned | 2018-05-30T08:14:19Z | - |
dc.date.available | 2018-05-30T08:14:19Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0022-3042 | - |
dc.identifier.other | OAK-3068 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/243596 | - |
dc.description.abstract | Flavonoids are naturally occurring polyphenolic compounds that have many biological properties, including antioxidative, anti-inflammatory and neuroprotective effects. Here, we report that amentoflavone significantly reduced cell death induced by staurosporine, etoposide and sodium nitroprusside in neuroblastoma SH-SY5Y cells. In post-natal day 7 rats, hypoxic-ischemic (H-I) brain damage induced by unilateral carotid ligation and hypoxia resulted in distinct features of neuronal cell death including apoptosis and necrosis. In this model, a systemic administration of amentoflavone (30 mg/kg) markedly reduced the H-I-induced brain tissue loss with a wide therapeutic time window up to 6 h after the onset of hypoxia. Amentoflavone blocked the activation of caspase 3, characteristic of apoptosis, and the proteolytic cleavage of its substrates following H-I injury. Amentoflavone also reduced the excitotoxic/necrotic cell death after H-I injury in vivo and after oxygen/glucose deprivation in mouse mixed cultures in vitro. Treatment of mouse microglial cells with amentoflavone resulted in a significant decrease in the lipopolysaccharide-induced production of nitric oxide and induction of inducible nitric oxide synthase and cyclo-oxygenase-2. Furthermore, amentoflavone decreased the inflammatory activation of microglia after H-I injury when assessed by the microglial-specific marker OX-42. These data demonstrate for the first time that amentoflavone strongly protects the neonatal brain from H-I injury by blocking multiple cellular events leading to brain damage. © 2005 International Society for Neurochemistry. | - |
dc.language | English | - |
dc.title | Polyphenol amentoflavone affords neuroprotection against neonatal hypoxic-ischemic brain damage via multiple mechanisms | - |
dc.type | Article | - |
dc.relation.issue | 2 | - |
dc.relation.volume | 96 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 561 | - |
dc.relation.lastpage | 572 | - |
dc.relation.journaltitle | Journal of Neurochemistry | - |
dc.identifier.doi | 10.1111/j.1471-4159.2005.03582.x | - |
dc.identifier.wosid | WOS:000234029100026 | - |
dc.identifier.scopusid | 2-s2.0-33644878337 | - |
dc.author.google | Shin D.H. | - |
dc.author.google | Bae Y.C. | - |
dc.author.google | Kim-Han J.S. | - |
dc.author.google | Lee J.H. | - |
dc.author.google | Choi I.Y. | - |
dc.author.google | Son K.H. | - |
dc.author.google | Kang S.S. | - |
dc.author.google | Kim W.-K. | - |
dc.author.google | Han B.H. | - |
dc.contributor.scopusid | 김원기(34770946200) | - |
dc.date.modifydate | 20211210152058 | - |