Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 윤영대 | - |
dc.date.accessioned | 2018-05-30T08:14:12Z | - |
dc.date.available | 2018-05-30T08:14:12Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0006-4971 | - |
dc.identifier.other | OAK-3170 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/243549 | - |
dc.description.abstract | Assembly of a signaling complex around the transmembrane adapter LAT is essential for the transmission of T-cell receptor (TCR)-mediated signaling. However, a LAT-like molecule responsible for the initial activation events in B-cell receptor (BCR) signaling has not yet been identified. Here, we show that LIME is a transmembrane adaptor required for BCR-mediated B-cell activation. LIME was found to be expressed in mouse splenic B cells. Upon BCR cross-linking, LIME was tyrosine phosphorylated by Lyn and associated with Lyn, Grb2, PLC-γ2, and PI3K. Reduction of LIME expression by the introduction of siRNA resulted in the disruption of BCR-mediated activation of MAPK, calcium flux, NF-AT, PI3K, and NF-κB. Taken together, these results establish that LIME is an essential transmembrane adaptor linking BCR ligation to the downstream signaling events that lead to B-cell activation. © 2006 by The American Society of Hematology. | - |
dc.language | English | - |
dc.title | LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation | - |
dc.type | Article | - |
dc.relation.issue | 4 | - |
dc.relation.volume | 107 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 1521 | - |
dc.relation.lastpage | 1527 | - |
dc.relation.journaltitle | Blood | - |
dc.identifier.doi | 10.1182/blood-2005-05-1859 | - |
dc.identifier.wosid | WOS:000235296100044 | - |
dc.identifier.scopusid | 2-s2.0-32644444038 | - |
dc.author.google | Ahn E. | - |
dc.author.google | Lee H. | - |
dc.author.google | Yun Y. | - |
dc.contributor.scopusid | 윤영대(7201731033) | - |
dc.date.modifydate | 20200901081003 | - |