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Neopikromycin and novapikromycin from the pikromycin biosynthetic pathway of Streptomyces venezuelae

Title
Neopikromycin and novapikromycin from the pikromycin biosynthetic pathway of Streptomyces venezuelae
Authors
Lee S.K.Park J.W.Kim J.W.Jung W.S.Park S.R.Choi C.Y.Kim E.S.Kim B.S.Ahn J.S.Sherman D.H.Yoon Y.J.
Ewha Authors
윤여준
SCOPUS Author ID
윤여준scopus
Issue Date
2006
Journal Title
Journal of Natural Products
ISSN
0163-3864JCR Link
Citation
Journal of Natural Products vol. 69, no. 5, pp. 847 - 849
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Two new macrolides from the pikromycin biosynthetic pathway of Streptomyces venezuelae, neopikromycin (9) and novapikromycin (10), were identified and structurally characterized through mass spectrometry and NMR spectroscopy. The established structures showed that 9 and 10 have hydroxyl groups at C-14 (9) and at both C-12 and C-14 (10), on the basis of a comparison with narbomycin (7). The purified PikC cytochrome P450 monooxygenase catalyzes the in vitro hydroxylation of 7 and pikromycin (8) to yield 9 and 10, respectively, thus expanding the substrate- and regio-flexibility of this enzyme. © 2006 American Chemical Society and American Society of Pharmacognosy.
DOI
10.1021/np060026p
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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