View : 581 Download: 0

Basic helix-loop-helix gene hes6 delineates the sensory hair cell lineage in the inner ear

Title
Basic helix-loop-helix gene hes6 delineates the sensory hair cell lineage in the inner ear
Authors
Qian D.Radde-Gallwitz K.Kelly M.Tyrberg B.Kim J.Gao W.-Q.Chen P.
Ewha Authors
김재상
SCOPUS Author ID
김재상scopus
Issue Date
2006
Journal Title
Developmental Dynamics
ISSN
1058-8388JCR Link
Citation
Developmental Dynamics vol. 235, no. 6, pp. 1689 - 1700
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
The basic helix-loop-helix (bHLH) gene Hes6 is known to promote neural differentiation in vitro. Here, we report the expression and functional studies of Hes6 in the inner ear. The expression of Hes6 appears to be parallel to that of Math1 (also known as Atoh1), a bHLH gene necessary and sufficient for hair cell differentiation. Hes6 is expressed initially in the presumptive hair cell precursors in the cochlea. Subsequently, the expression of Hes6 is restricted to morphologically differentiated hair cells. Similarly, the expression of Hes6 in the vestibule is in the hair cell lineage. Hes6 is dispensable for hair cell differentiation, and its expression in inner ear hair cells is abolished in the Math1-null animals. Furthermore, the introduction of Hes6 into the cochlea in vitro is not sufficient to promote sensory or neuronal differentiation. Therefore, Hes6 is downstream of Math1 and its expression in the inner ear delineates the sensory lineage. However, the role of Hes6 in the inner ear remains elusive. © 2006 Wiley-Liss, Inc.
DOI
10.1002/dvdy.20736
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

BROWSE