Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이승진 | - |
dc.date.accessioned | 2018-05-30T08:13:54Z | - |
dc.date.available | 2018-05-30T08:13:54Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0141-8130 | - |
dc.identifier.other | OAK-3391 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/243426 | - |
dc.description.abstract | Electrospinning of chitin/silk fibroin (SF) blend solutions in 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) was investigated to fabricate a biomimetic nanostructured scaffolds for tissue engineering. The morphology of the electrospun chitin/SF blend nanofibers was investigated with a field emission scanning electron microscope (FE-SEM). The average diameters of chitin/SF blend fibers decreased from 920 to 340 nm, with the increase of chitin content in blend compositions. The miscibility of chitin/SF blend fibers was examined by solution viscosity measurement. The chitin and SF were immiscible in the as-spun nanofibrous structure. The dimensional stability of chitin/SF blend nanofibers, with or without water vapor after-treatment, was conducted by immersing in water. As-spun SF-rich blend nanofibrous matrices were lost their fibrous structure after the water immersion for 24 h, and then changed into membrane-like structure. On the contrary, nanofibrous structures of water vapor-treated SF-rich blends were almost maintained. To assay the cytocompatibility and cell behavior on the chitin/SF blend nanofibrous scaffolds, cell attachment and spreading of normal human epidermal keratinocyte and fibroblasts seeded on the scaffolds were studied. Our results indicate that chitin/SF blend nanofibrous matrix, particularly the one that contained 75% chitin and 25% SF, could be a potential candidate for tissue engineering scaffolds because it has both biomimetic three-dimensional structure and an excellent cell attachment and spreading for NHEK and NHEF. © 2006 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.title | Biomimetic nanofibrous scaffolds: Preparation and characterization of chitin/silk fibroin blend nanofibers | - |
dc.type | Article | - |
dc.relation.issue | 3-5 | - |
dc.relation.volume | 38 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 165 | - |
dc.relation.lastpage | 173 | - |
dc.relation.journaltitle | International Journal of Biological Macromolecules | - |
dc.identifier.doi | 10.1016/j.ijbiomac.2006.03.003 | - |
dc.identifier.wosid | WOS:000238334000002 | - |
dc.identifier.scopusid | 2-s2.0-33646673846 | - |
dc.author.google | Park K.E. | - |
dc.author.google | Jung S.Y. | - |
dc.author.google | Lee S.J. | - |
dc.author.google | Min B.-M. | - |
dc.author.google | Park W.H. | - |
dc.contributor.scopusid | 이승진(57196249292) | - |
dc.date.modifydate | 20230118105419 | - |